TY - JOUR
T1 - Subthalamic, not striatal, activity correlates with basal ganglia downstream activity in normal and parkinsonian monkeys
AU - Deffains, Marc
AU - Iskhakova, Liliya
AU - Katabi, Shiran
AU - Haber, Suzanne N.
AU - Israel, Zvi
AU - Bergman, Hagai
N1 - Publisher Copyright:
© Deffains et al.
PY - 2016/8/23
Y1 - 2016/8/23
N2 - The striatum and the subthalamic nucleus (STN) constitute the input stage of the basal ganglia (BG) network and together innervate BG downstream structures using GABA and glutamate, respectively. Comparison of the neuronal activity in BG input and downstream structures reveals that subthalamic, not striatal, activity fluctuations correlate with modulations in the increase/decrease discharge balance of BG downstream neurons during temporal discounting classical condition task. After induction of parkinsonism with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), abnormal low beta (8-15 Hz) spiking and local field potential (LFP) oscillations resonate across the BG network. Nevertheless, LFP beta oscillations entrain spiking activity of STN, striatal cholinergic interneurons and BG downstream structures, but do not entrain spiking activity of striatal projection neurons. Our results highlight the pivotal role of STN divergent projections in BG physiology and pathophysiology and may explain why STN is such an effective site for invasive treatment of advanced Parkinson's disease and other BG-related disorders.
AB - The striatum and the subthalamic nucleus (STN) constitute the input stage of the basal ganglia (BG) network and together innervate BG downstream structures using GABA and glutamate, respectively. Comparison of the neuronal activity in BG input and downstream structures reveals that subthalamic, not striatal, activity fluctuations correlate with modulations in the increase/decrease discharge balance of BG downstream neurons during temporal discounting classical condition task. After induction of parkinsonism with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), abnormal low beta (8-15 Hz) spiking and local field potential (LFP) oscillations resonate across the BG network. Nevertheless, LFP beta oscillations entrain spiking activity of STN, striatal cholinergic interneurons and BG downstream structures, but do not entrain spiking activity of striatal projection neurons. Our results highlight the pivotal role of STN divergent projections in BG physiology and pathophysiology and may explain why STN is such an effective site for invasive treatment of advanced Parkinson's disease and other BG-related disorders.
UR - http://www.scopus.com/inward/record.url?scp=84988487600&partnerID=8YFLogxK
U2 - 10.7554/eLife.16443
DO - 10.7554/eLife.16443
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C2 - 27552049
AN - SCOPUS:84988487600
SN - 2050-084X
VL - 5
JO - eLife
JF - eLife
IS - AUGUST
M1 - e16443
ER -