TY - JOUR
T1 - Subthalamic nucleus input-output dynamics are correlated with Parkinson’s burden and treatment efficacy
AU - Liu, Xiaowei
AU - Guang, Jing
AU - Glowinsky, Stefanie
AU - Abadi, Hodaya
AU - Arkadir, David
AU - Linetsky, Eduard
AU - Abu Snineh, Muneer
AU - León, Juan F.
AU - Israel, Zvi
AU - Wang, Wei
AU - Bergman, Hagai
N1 - Publisher Copyright:
© The Author(s) 2024.
PY - 2024/12
Y1 - 2024/12
N2 - The subthalamic nucleus (STN) is pivotal in basal ganglia function in health and disease. Micro-electrode recordings of >25,000 recording sites from 146 Parkinson’s patients undergoing deep brain stimulation (DBS) allowed differentiation between subthalamic input, represented by local field potential (LFP), and output, reflected in spike discharge rate (SPK). As with many natural systems, STN neuronal activity exhibits power-law dynamics characterized by the exponent α. We, therefore, dissected STN data into aperiodic and periodic components using the Fitting Oscillations & One Over F (FOOOF) tool. STN LFP showed significantly higher aperiodic exponents than SPK. Additionally, SPK beta oscillations demonstrated a downward frequency shift compared to LFP. Finally, the STN aperiodic and spiking parameters explained a significant fraction of the variance of the burden and treatment efficacy of Parkinson’s disease. The unique STN input-output dynamics may clarify its role in Parkinson’s physiology and can be utilized in closed-loop DBS therapy.
AB - The subthalamic nucleus (STN) is pivotal in basal ganglia function in health and disease. Micro-electrode recordings of >25,000 recording sites from 146 Parkinson’s patients undergoing deep brain stimulation (DBS) allowed differentiation between subthalamic input, represented by local field potential (LFP), and output, reflected in spike discharge rate (SPK). As with many natural systems, STN neuronal activity exhibits power-law dynamics characterized by the exponent α. We, therefore, dissected STN data into aperiodic and periodic components using the Fitting Oscillations & One Over F (FOOOF) tool. STN LFP showed significantly higher aperiodic exponents than SPK. Additionally, SPK beta oscillations demonstrated a downward frequency shift compared to LFP. Finally, the STN aperiodic and spiking parameters explained a significant fraction of the variance of the burden and treatment efficacy of Parkinson’s disease. The unique STN input-output dynamics may clarify its role in Parkinson’s physiology and can be utilized in closed-loop DBS therapy.
UR - http://www.scopus.com/inward/record.url?scp=85196023593&partnerID=8YFLogxK
U2 - 10.1038/s41531-024-00737-8
DO - 10.1038/s41531-024-00737-8
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C2 - 38879564
AN - SCOPUS:85196023593
SN - 2373-8057
VL - 10
JO - npj Parkinson's Disease
JF - npj Parkinson's Disease
IS - 1
M1 - 117
ER -