Successful Treatment of Antibiotic-resistant, Poly-microbial Bone Infection with Bacteriophages and Antibiotics Combination

Ran Nir-Paz; Daniel Gelman; Ayman Khouri; Brittany M. Sisson; Joseph Fackler; Sivan Alkalay-Oren; Leron Khalifa; Amit Rimon; Ortal Yerushalmy; Reem Bader; Sharon Amit; Shunit Coppenhagen-Glazer; Matthew Henry; Javier Quinones; Francisco Malagon; Biswajit Biswas; Allon E. Moses; Greg Merril; Robert T. Schooley; Michael J. Brownstein; Yoram A. Weil; Ronen Hazan

doi:10.1093/cid/ciz222

Successful Treatment of Antibiotic-resistant, Poly-microbial Bone Infection with Bacteriophages and Antibiotics Combination

Ran Nir-Paz^*, Daniel Gelman, Ayman Khouri, Brittany M. Sisson, Joseph Fackler, Sivan Alkalay-Oren, Leron Khalifa, Amit Rimon, Ortal Yerushalmy, Reem Bader, Sharon Amit, Shunit Coppenhagen-Glazer, Matthew Henry, Javier Quinones, Francisco Malagon, Biswajit Biswas, Allon E. Moses, Greg Merril, Robert T. Schooley, Michael J. BrownsteinYoram A. Weil, Ronen Hazan

^*Corresponding author for this work

Institute of Biomedical Research at the Faculty of Dental Medicine

Research output: Contribution to journal › Article › peer-review

155 Scopus citations

Abstract

A patient with a trauma-related left tibial infection associated with extensively drug-resistant Acinetobacter baumannii and multidrug-resistant Klebsiella pneumoniae was treated with bacteriophages and antibiotics. There was rapid tissue healing and positive culture eradication. As a result, the patient's leg did not have to be amputated and he is undergoing rehabilitation.

Original language	English
Pages (from-to)	2015-2018
Number of pages	4
Journal	Clinical Infectious Diseases
Volume	69
Issue number	11
DOIs	https://doi.org/10.1093/cid/ciz222
State	Published - 13 Nov 2019

Bibliographical note

Publisher Copyright:
© 2019 The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: [email protected].

Keywords

antibiotic resistance
bacteriophage
orthopedic infections
phage
phage therapy

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/cid/ciz222

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Nir-Paz, R., Gelman, D., Khouri, A., Sisson, B. M., Fackler, J., Alkalay-Oren, S., Khalifa, L., Rimon, A., Yerushalmy, O., Bader, R., Amit, S., Coppenhagen-Glazer, S., Henry, M., Quinones, J., Malagon, F., Biswas, B., Moses, A. E., Merril, G., Schooley, R. T., ... Hazan, R. (2019). Successful Treatment of Antibiotic-resistant, Poly-microbial Bone Infection with Bacteriophages and Antibiotics Combination. Clinical Infectious Diseases, 69(11), 2015-2018. https://doi.org/10.1093/cid/ciz222

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title = "Successful Treatment of Antibiotic-resistant, Poly-microbial Bone Infection with Bacteriophages and Antibiotics Combination",

abstract = "A patient with a trauma-related left tibial infection associated with extensively drug-resistant Acinetobacter baumannii and multidrug-resistant Klebsiella pneumoniae was treated with bacteriophages and antibiotics. There was rapid tissue healing and positive culture eradication. As a result, the patient's leg did not have to be amputated and he is undergoing rehabilitation.",

keywords = "antibiotic resistance, bacteriophage, orthopedic infections, phage, phage therapy",

author = "Ran Nir-Paz and Daniel Gelman and Ayman Khouri and Sisson, {Brittany M.} and Joseph Fackler and Sivan Alkalay-Oren and Leron Khalifa and Amit Rimon and Ortal Yerushalmy and Reem Bader and Sharon Amit and Shunit Coppenhagen-Glazer and Matthew Henry and Javier Quinones and Francisco Malagon and Biswajit Biswas and Moses, {Allon E.} and Greg Merril and Schooley, {Robert T.} and Brownstein, {Michael J.} and Weil, {Yoram A.} and Ronen Hazan",

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doi = "10.1093/cid/ciz222",

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Nir-Paz, R, Gelman, D, Khouri, A, Sisson, BM, Fackler, J, Alkalay-Oren, S, Khalifa, L, Rimon, A, Yerushalmy, O, Bader, R, Amit, S, Coppenhagen-Glazer, S, Henry, M, Quinones, J, Malagon, F, Biswas, B, Moses, AE, Merril, G, Schooley, RT, Brownstein, MJ, Weil, YA & Hazan, R 2019, 'Successful Treatment of Antibiotic-resistant, Poly-microbial Bone Infection with Bacteriophages and Antibiotics Combination', Clinical Infectious Diseases, vol. 69, no. 11, pp. 2015-2018. https://doi.org/10.1093/cid/ciz222

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AU - Nir-Paz, Ran

AU - Gelman, Daniel

AU - Khouri, Ayman

AU - Sisson, Brittany M.

AU - Fackler, Joseph

AU - Alkalay-Oren, Sivan

AU - Khalifa, Leron

AU - Rimon, Amit

AU - Yerushalmy, Ortal

AU - Bader, Reem

AU - Amit, Sharon

AU - Coppenhagen-Glazer, Shunit

AU - Henry, Matthew

AU - Quinones, Javier

AU - Malagon, Francisco

AU - Biswas, Biswajit

AU - Moses, Allon E.

AU - Merril, Greg

AU - Schooley, Robert T.

AU - Brownstein, Michael J.

AU - Weil, Yoram A.

AU - Hazan, Ronen

N1 - Publisher Copyright: © 2019 The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: [email protected].

PY - 2019/11/13

Y1 - 2019/11/13

N2 - A patient with a trauma-related left tibial infection associated with extensively drug-resistant Acinetobacter baumannii and multidrug-resistant Klebsiella pneumoniae was treated with bacteriophages and antibiotics. There was rapid tissue healing and positive culture eradication. As a result, the patient's leg did not have to be amputated and he is undergoing rehabilitation.

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KW - bacteriophage

KW - orthopedic infections

KW - phage

KW - phage therapy

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Successful Treatment of Antibiotic-resistant, Poly-microbial Bone Infection with Bacteriophages and Antibiotics Combination

Abstract

Bibliographical note

Keywords

UN SDGs

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