A patient with a trauma-related left tibial infection associated with extensively drug-resistant Acinetobacter baumannii and multidrug-resistant Klebsiella pneumoniae was treated with bacteriophages and antibiotics. There was rapid tissue healing and positive culture eradication. As a result, the patient's leg did not have to be amputated and he is undergoing rehabilitation.
Bibliographical noteFunding Information:
1Department of Clinical Microbiology and Infectious Diseases, Hadassah-Hebrew University Medical Center, 2Institute of Dental Sciences, Faculty of Dental Medicine, The Hebrew University, 3Tzameret, The Military Track of Medicine, The Hebrew University-Hadassah Medical School, and 4Orthopedic Surgery Department, Hadassah-Hebrew University Medical Center, Jerusalem, Israel; and 5Adaptive Phage Therapeutics, Gaithersburg, and 6The Geneva Foundation and Biological Defense Research Directorate Naval Medical Research Center, Frederick, Maryland; and 7Department of Medicine, Division of Infectious Diseases, University of California San Diego, La Jolla, California
Financial support. This work was supported by Milgrom (trust grant to R. H.); the United States–Israel Binational Science Foundation (grant number 2017123 to R. H., R. T. S., and R. N.-P.); the Israel Science Foundation (grant number ISF_540_2017 to R. H.); and the Rosetrees Trust (grant number A2232 to R. H.).
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- antibiotic resistance
- orthopedic infections
- phage therapy