Successful Treatment of Antibiotic-resistant, Poly-microbial Bone Infection with Bacteriophages and Antibiotics Combination

Ran Nir-Paz*, Daniel Gelman, Ayman Khouri, Brittany M. Sisson, Joseph Fackler, Sivan Alkalay-Oren, Leron Khalifa, Amit Rimon, Ortal Yerushalmy, Reem Bader, Sharon Amit, Shunit Coppenhagen-Glazer, Matthew Henry, Javier Quinones, Francisco Malagon, Biswajit Biswas, Allon E. Moses, Greg Merril, Robert T. Schooley, Michael J. BrownsteinYoram A. Weil, Ronen Hazan

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

121 Scopus citations


A patient with a trauma-related left tibial infection associated with extensively drug-resistant Acinetobacter baumannii and multidrug-resistant Klebsiella pneumoniae was treated with bacteriophages and antibiotics. There was rapid tissue healing and positive culture eradication. As a result, the patient's leg did not have to be amputated and he is undergoing rehabilitation.

Original languageAmerican English
Pages (from-to)2015-2018
Number of pages4
JournalClinical Infectious Diseases
Issue number11
StatePublished - 13 Nov 2019

Bibliographical note

Funding Information:
1Department of Clinical Microbiology and Infectious Diseases, Hadassah-Hebrew University Medical Center, 2Institute of Dental Sciences, Faculty of Dental Medicine, The Hebrew University, 3Tzameret, The Military Track of Medicine, The Hebrew University-Hadassah Medical School, and 4Orthopedic Surgery Department, Hadassah-Hebrew University Medical Center, Jerusalem, Israel; and 5Adaptive Phage Therapeutics, Gaithersburg, and 6The Geneva Foundation and Biological Defense Research Directorate Naval Medical Research Center, Frederick, Maryland; and 7Department of Medicine, Division of Infectious Diseases, University of California San Diego, La Jolla, California

Funding Information:
Financial support. This work was supported by Milgrom (trust grant to R.  H.); the United States–Israel Binational Science Foundation (grant number 2017123 to R. H., R. T. S., and R. N.-P.); the Israel Science Foundation (grant number ISF_540_2017 to R. H.); and the Rosetrees Trust (grant number A2232 to R. H.).

Publisher Copyright:
© 2019 The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail:


  • antibiotic resistance
  • bacteriophage
  • orthopedic infections
  • phage
  • phage therapy


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