Successful Treatment of Antibiotic-resistant, Poly-microbial Bone Infection with Bacteriophages and Antibiotics Combination

Ran Nir-Paz*, Daniel Gelman, Ayman Khouri, Brittany M. Sisson, Joseph Fackler, Sivan Alkalay-Oren, Leron Khalifa, Amit Rimon, Ortal Yerushalmy, Reem Bader, Sharon Amit, Shunit Coppenhagen-Glazer, Matthew Henry, Javier Quinones, Francisco Malagon, Biswajit Biswas, Allon E. Moses, Greg Merril, Robert T. Schooley, Michael J. BrownsteinYoram A. Weil, Ronen Hazan

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

141 Scopus citations

Abstract

A patient with a trauma-related left tibial infection associated with extensively drug-resistant Acinetobacter baumannii and multidrug-resistant Klebsiella pneumoniae was treated with bacteriophages and antibiotics. There was rapid tissue healing and positive culture eradication. As a result, the patient's leg did not have to be amputated and he is undergoing rehabilitation.

Original languageAmerican English
Pages (from-to)2015-2018
Number of pages4
JournalClinical Infectious Diseases
Volume69
Issue number11
DOIs
StatePublished - 13 Nov 2019

Bibliographical note

Publisher Copyright:
© 2019 The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.

Keywords

  • antibiotic resistance
  • bacteriophage
  • orthopedic infections
  • phage
  • phage therapy

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