Sugar-induced apoptosis in yeast cells

David Granot*, Alex Levine, Edan Dor-Hefetz

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

99 Scopus citations


Sugars induce death of Saccharomyces cerevisiae within a few hours in the absence of additional nutrients to support growth; by contrast, cells incubated in water or in the presence of other nutrients without sugar remain viable for weeks. Here we show that this sugar-induced cell death (SICD) is characterized by rapid production of reactive oxygen species (ROS), RNA and DNA degradation, membrane damage, nucleus fragmentation and cell shrinkage. Addition of ascorbic acid to sugar-incubated cells prevents SICD, indicating that SICD is initiated by ROS. The lack of a protection mechanism against SICD suggests that sugars use to be the limiting nutrients for yeast and are probably depleted before all other nutrients. Being the limiting nutrient, sugars became the growth-stimulating agent, signaling the presence of sufficient nutrients for growth, but in the absence of the complementing nutrients they induce apoptotic death.

Original languageAmerican English
Pages (from-to)7-13
Number of pages7
JournalFEMS Yeast Research
Issue number1
StatePublished - Oct 2003

Bibliographical note

Funding Information:
This research was supported by research Grant no. IS-3226-02C from BARD, The united States-Israel Binational Agricultural Research and Development Fund, by BSF Grant 97-00250, and by The Israel Science Foundation Grant no. 582/01-2. Contribution from the Agriculture Research Organization, The Volcani Center, Bet Dagan, Israel, No. 149/2002.


  • Apoptosis
  • Growth stimulation
  • Programmed cell death
  • Saccharomyces cerevisiae
  • Starvation


Dive into the research topics of 'Sugar-induced apoptosis in yeast cells'. Together they form a unique fingerprint.

Cite this