SUN-domain and KASH-domain proteins during development, meiosis and disease

A. Fridkin, A. Penkner, V. Jantsch*, Y. Gruenbaum

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

77 Scopus citations

Abstract

SUN-domain proteins interact directly with KASH-domain proteins to form protein complexes that connect the nucleus to every major cytoskeleton network. SUN-KASH protein complexes are also required for attaching centrosomes to the nuclear periphery and for alignment of homologous chromosomes, their pairing and recombination in meiosis. Other functions that require SUN-domain proteins include the regulation of apoptosis and maturation and survival of the germline. Laminopathic diseases affect the distribution of the SUN-KASH complexes, and mutations in KASH-domain proteins can cause Emery Dreifuss muscular dystrophy and recessive cerebellar ataxia. This review describes our current knowledge of the role of SUN-KASH domain protein complexes during development, meiosis and disease.

Original languageEnglish
Pages (from-to)1518-1533
Number of pages16
JournalCellular and Molecular Life Sciences
Volume66
Issue number9
DOIs
StatePublished - Jan 2009

Keywords

  • Centrosome
  • Cytoskeleton
  • Emery Dreifuss muscular dystrophy
  • Homologous pairing
  • Meiosis
  • Nuclear positioning

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