Abstract
SUN-domain proteins interact directly with KASH-domain proteins to form protein complexes that connect the nucleus to every major cytoskeleton network. SUN-KASH protein complexes are also required for attaching centrosomes to the nuclear periphery and for alignment of homologous chromosomes, their pairing and recombination in meiosis. Other functions that require SUN-domain proteins include the regulation of apoptosis and maturation and survival of the germline. Laminopathic diseases affect the distribution of the SUN-KASH complexes, and mutations in KASH-domain proteins can cause Emery Dreifuss muscular dystrophy and recessive cerebellar ataxia. This review describes our current knowledge of the role of SUN-KASH domain protein complexes during development, meiosis and disease.
Original language | English |
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Pages (from-to) | 1518-1533 |
Number of pages | 16 |
Journal | Cellular and Molecular Life Sciences |
Volume | 66 |
Issue number | 9 |
DOIs | |
State | Published - Jan 2009 |
Keywords
- Centrosome
- Cytoskeleton
- Emery Dreifuss muscular dystrophy
- Homologous pairing
- Meiosis
- Nuclear positioning