SUN-domain proteins: 'Velcro' that links the nucleoskeleton to the cytoskeleton

Yonatan B. Tzur, Katherine L. Wilson*, Yosef Gruenbaum

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

197 Scopus citations


The novel SUN-domain family of nuclear envelope proteins interacts with various KASH-domain partners to form SUN-domain-dependent 'bridges' across the inner and outer nuclear membranes. These bridges physically connect the nucleus to every major component of the cytoskeleton. SUN-domain proteins have diverse roles in nuclear positioning, centrosome localization, germ-cell development, telomere positioning and apoptosis. By serving both as mechanical adaptors and nuclear envelope receptors, we propose that SUN-domain proteins connect cytoplasmic and nucleoplasmic activities.

Original languageAmerican English
Pages (from-to)782-788
Number of pages7
JournalNature Reviews Molecular Cell Biology
Issue number10
StatePublished - 23 Oct 2006

Bibliographical note

Funding Information:
We gratefully acknowledge support from the Israel Science Foundation (ISF), Israel–USA Binational Science Foundation (BSF) and the European Union’s FP6, Life Science, Genomics and Biotechnology for Health to Y.G., and the National Institutes of Health to K.L.W.

Funding Information:
Work in the laboratory of P.G.S. is supported by the National Institutes of Health, the United States Department of Energy and the Skaggs Institute for Chemical Biology.


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