1H‐NMR studies on substance P hexapeptide analogs

Anthony Ribeiro*, Oleg Jardetzky, Chaim Gilon, Dina Teitelbaum, Michael Chorev

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

1H‐nmr studies of [pGlu6]SP6–11, [gpGlu6,mPhe7]SP6–11, and [pGlu6,N‐CH3Phe7]SP6–11 in DMSO‐d6 reveal characteristic chemical shifts, 3JNH‐αCH, temperature dependence, as well as deuterium exchange half‐times. Marked similarities are revealed for the two first analogs, whereas the N‐methylated analog is clearly different. Possible conformations are considered.

Original languageEnglish
Pages (from-to)247-253
Number of pages7
JournalBiopolymers
Volume22
Issue number1
DOIs
StatePublished - Jan 1983

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