1H‐NMR studies on substance P hexapeptide analogs

Anthony Ribeiro; Oleg Jardetzky; Chaim Gilon; Dina Teitelbaum; Michael Chorev

doi:10.1002/bip.360220134

¹H‐NMR studies on substance P hexapeptide analogs

Anthony Ribeiro^*
, Oleg Jardetzky
, Chaim Gilon
, Dina Teitelbaum
, Michael Chorev

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

¹H‐nmr studies of [pGlu⁶]SP_6–11, [gpGlu⁶,mPhe⁷]SP_6–11, and [pGlu⁶,N‐CH₃Phe⁷]SP_6–11 in DMSO‐d₆ reveal characteristic chemical shifts, ³J_NH‐αCH, temperature dependence, as well as deuterium exchange half‐times. Marked similarities are revealed for the two first analogs, whereas the N‐methylated analog is clearly different. Possible conformations are considered.

Original language	English
Pages (from-to)	247-253
Number of pages	7
Journal	Biopolymers
Volume	22
Issue number	1
DOIs	https://doi.org/10.1002/bip.360220134
State	Published - Jan 1983

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title = "1H‐NMR studies on substance P hexapeptide analogs",

abstract = "1H‐nmr studies of [pGlu6]SP6–11, [gpGlu6,mPhe7]SP6–11, and [pGlu6,N‐CH3Phe7]SP6–11 in DMSO‐d6 reveal characteristic chemical shifts, 3JNH‐αCH, temperature dependence, as well as deuterium exchange half‐times. Marked similarities are revealed for the two first analogs, whereas the N‐methylated analog is clearly different. Possible conformations are considered.",

author = "Anthony Ribeiro and Oleg Jardetzky and Chaim Gilon and Dina Teitelbaum and Michael Chorev",

year = "1983",

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T1 - 1H‐NMR studies on substance P hexapeptide analogs

AU - Ribeiro, Anthony

AU - Jardetzky, Oleg

AU - Gilon, Chaim

AU - Teitelbaum, Dina

AU - Chorev, Michael

PY - 1983/1

Y1 - 1983/1

N2 - 1H‐nmr studies of [pGlu6]SP6–11, [gpGlu6,mPhe7]SP6–11, and [pGlu6,N‐CH3Phe7]SP6–11 in DMSO‐d6 reveal characteristic chemical shifts, 3JNH‐αCH, temperature dependence, as well as deuterium exchange half‐times. Marked similarities are revealed for the two first analogs, whereas the N‐methylated analog is clearly different. Possible conformations are considered.

AB - 1H‐nmr studies of [pGlu6]SP6–11, [gpGlu6,mPhe7]SP6–11, and [pGlu6,N‐CH3Phe7]SP6–11 in DMSO‐d6 reveal characteristic chemical shifts, 3JNH‐αCH, temperature dependence, as well as deuterium exchange half‐times. Marked similarities are revealed for the two first analogs, whereas the N‐methylated analog is clearly different. Possible conformations are considered.

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¹H‐NMR studies on substance P hexapeptide analogs

Abstract

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