Super-resolution photoacoustic fluctuation imaging with multiple speckle illumination

Thomas Chaigne*, Jérôme Gateau, Marc Allain, Ori Katz, Sylvain Gigan, Anne Sentenac, Emmanuel Bossy

*Corresponding author for this work

Research output: Contribution to journalLetterpeer-review

62 Scopus citations

Abstract

In deep tissue photoacoustic imaging, the spatial resolution is inherently limited by acoustic diffraction. Moreover, as the ultrasound attenuation increases with frequency, resolution is often traded off for penetration depth. Here, we report on super-resolution photoacoustic imaging by use of multiple speckle illumination. Specifically, we demonstrate experimentally that the analysis of second-order fluctuations of the photoacoustic images enables the resolution of optically absorbing structures beyond the acoustic diffraction limit, with a resolution enhancement of about 1.4. In addition, deconvolution was implemented to fully exploit the highest spatial frequencies available and resulted in an effective resolution enhancement of at least 1.6 in the lateral direction. Our method introduces a new framework that could potentially lead to deep tissue photoacoustic imaging with subacoustic resolution.

Original languageAmerican English
Pages (from-to)54-57
Number of pages4
JournalOptica
Volume3
Issue number1
DOIs
StatePublished - 12 Jan 2016
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2016 Optical Society of America.

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