TY - JOUR
T1 - Superinfection of EBV-carrying lines with Herpes virus papio (HVP)
T2 - Induction of early antigen (EA) and inhibition of cellular DNA synthesis
AU - Steinitz, Michael
AU - Klein, George
PY - 1979/2
Y1 - 1979/2
N2 - An Epstein-Barr virus (EBV) related herpes virus H. papio (HVP) derived from 9B cell line was shown to inhibit the DNA synthesis in B-cell mitogen stimulated human lymphocytes, in B95-8 virus exposed human lymphocytes, and the DNA metabolism of EBV-receptor positive cell lines. The inhibition could be abolished by a Burkitt serum known to have a high anti-EBV titer. Similar inhibition activities were shown for P3HR-1 virus. The relationship between the inability to immortalize normal cells, the ability to induce early antigen (EA) in certain cell lines and the DNA inhibitory effect of both 9B and P3HR-1 viruses is discussed.
AB - An Epstein-Barr virus (EBV) related herpes virus H. papio (HVP) derived from 9B cell line was shown to inhibit the DNA synthesis in B-cell mitogen stimulated human lymphocytes, in B95-8 virus exposed human lymphocytes, and the DNA metabolism of EBV-receptor positive cell lines. The inhibition could be abolished by a Burkitt serum known to have a high anti-EBV titer. Similar inhibition activities were shown for P3HR-1 virus. The relationship between the inability to immortalize normal cells, the ability to induce early antigen (EA) in certain cell lines and the DNA inhibitory effect of both 9B and P3HR-1 viruses is discussed.
UR - http://www.scopus.com/inward/record.url?scp=0018349028&partnerID=8YFLogxK
U2 - 10.1016/0014-2964(79)90063-X
DO - 10.1016/0014-2964(79)90063-X
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
C2 - 220052
AN - SCOPUS:0018349028
SN - 0014-2964
VL - 15
SP - 217
EP - 222
JO - European Journal of Cancer (1965)
JF - European Journal of Cancer (1965)
IS - 2
ER -
