Supersensitive odorant receptor underscores pleiotropic roles of indoles in mosquito ecology

David Ruel, Esther Yakir, Jonathan D. Bohbot*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

Mosquitoes exhibit highly diverse and fast evolving odorant receptors (ORs). The indole-sensitive OR gene clade, comprised of Or2 and Or10 is a notable exception on account of its conservation in both mosquito subfamilies. This group of paralogous genes exhibits a complex developmental expression pattern in Aedes aegypti: AaegOr2 is expressed in both adults and larvae, AaegOr10 is adult-specific and a third member named AaegOr9 is larva-specific. OR2 and OR10 have been deorphanized and are selectively activated by indole and skatole, respectively. Using the two-electrode voltage clamp of Xenopus oocytes expressing Ae. aegypti ORs, we show that AaegOR9 is supersensitive and narrowly tuned to skatole. Our findings suggest that Ae. aegypti has evolved two distinct molecular strategies to detect skatole in aquatic and terrestrial environments, highlighting the central ecological roles of indolic compounds in the evolutionary and life histories of these insects.

Original languageAmerican English
Article number533
JournalFrontiers in Cellular Neuroscience
Volume12
DOIs
StatePublished - 4 Jan 2019

Bibliographical note

Publisher Copyright:
© 2019 Ruel, Yakir and Bohbot.

Keywords

  • Aedes aegypti
  • Indole
  • Mosquito
  • Odorant receptor
  • Skatole

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