TY - JOUR
T1 - SUPERSENSITIVITY TO ISOPRENALINE INDUCED IN RATS BY PROLONGED ISOLATION
AU - SPEISER, ZIPORA
AU - WEINSTOCK, MARTA
PY - 1974/12
Y1 - 1974/12
N2 - The effect of isoprenaline on diastolic blood pressure and heart rate was determined in anaesthetized male rats which had been housed individually for 6–8 weeks after weaning, and compared with its effect in group‐housed litter‐mate controls. Isoprenaline caused a significantly greater fall in diastolic pressure in isolated rats and a greater increase in heart rate. Low doses of noradrenaline (5–10 ng) caused vasodepressor responses in isolated, but not in group‐housed rats. The pressor response to noradrenaline, which was smaller in isolated rats, was increased to the level of group‐housed controls by (±)‐propranolol. Prolonged isolation of rats may bring about an increase in sensitivity of β‐adrenoceptors to isoprenaline and noradrenaline. 1974 British Pharmacological Society
AB - The effect of isoprenaline on diastolic blood pressure and heart rate was determined in anaesthetized male rats which had been housed individually for 6–8 weeks after weaning, and compared with its effect in group‐housed litter‐mate controls. Isoprenaline caused a significantly greater fall in diastolic pressure in isolated rats and a greater increase in heart rate. Low doses of noradrenaline (5–10 ng) caused vasodepressor responses in isolated, but not in group‐housed rats. The pressor response to noradrenaline, which was smaller in isolated rats, was increased to the level of group‐housed controls by (±)‐propranolol. Prolonged isolation of rats may bring about an increase in sensitivity of β‐adrenoceptors to isoprenaline and noradrenaline. 1974 British Pharmacological Society
UR - http://www.scopus.com/inward/record.url?scp=0016266041&partnerID=8YFLogxK
U2 - 10.1111/j.1476-5381.1974.tb09730.x
DO - 10.1111/j.1476-5381.1974.tb09730.x
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C2 - 4455336
AN - SCOPUS:0016266041
SN - 0007-1188
VL - 52
SP - 605
EP - 608
JO - British Journal of Pharmacology
JF - British Journal of Pharmacology
IS - 4
ER -