SUPERSENSITIVITY TO ISOPRENALINE INDUCED IN RATS BY PROLONGED ISOLATION

ZIPORA SPEISER; MARTA WEINSTOCK

doi:10.1111/j.1476-5381.1974.tb09730.x

SUPERSENSITIVITY TO ISOPRENALINE INDUCED IN RATS BY PROLONGED ISOLATION

ZIPORA SPEISER^*
, MARTA WEINSTOCK

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

The effect of isoprenaline on diastolic blood pressure and heart rate was determined in anaesthetized male rats which had been housed individually for 6–8 weeks after weaning, and compared with its effect in group‐housed litter‐mate controls. Isoprenaline caused a significantly greater fall in diastolic pressure in isolated rats and a greater increase in heart rate. Low doses of noradrenaline (5–10 ng) caused vasodepressor responses in isolated, but not in group‐housed rats. The pressor response to noradrenaline, which was smaller in isolated rats, was increased to the level of group‐housed controls by (±)‐propranolol. Prolonged isolation of rats may bring about an increase in sensitivity of β‐adrenoceptors to isoprenaline and noradrenaline. 1974 British Pharmacological Society

Original language	English
Pages (from-to)	605-608
Number of pages	4
Journal	British Journal of Pharmacology
Volume	52
Issue number	4
DOIs	https://doi.org/10.1111/j.1476-5381.1974.tb09730.x
State	Published - Dec 1974
Externally published	Yes

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abstract = "The effect of isoprenaline on diastolic blood pressure and heart rate was determined in anaesthetized male rats which had been housed individually for 6–8 weeks after weaning, and compared with its effect in group‐housed litter‐mate controls. Isoprenaline caused a significantly greater fall in diastolic pressure in isolated rats and a greater increase in heart rate. Low doses of noradrenaline (5–10 ng) caused vasodepressor responses in isolated, but not in group‐housed rats. The pressor response to noradrenaline, which was smaller in isolated rats, was increased to the level of group‐housed controls by (±)‐propranolol. Prolonged isolation of rats may bring about an increase in sensitivity of β‐adrenoceptors to isoprenaline and noradrenaline. 1974 British Pharmacological Society",

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AB - The effect of isoprenaline on diastolic blood pressure and heart rate was determined in anaesthetized male rats which had been housed individually for 6–8 weeks after weaning, and compared with its effect in group‐housed litter‐mate controls. Isoprenaline caused a significantly greater fall in diastolic pressure in isolated rats and a greater increase in heart rate. Low doses of noradrenaline (5–10 ng) caused vasodepressor responses in isolated, but not in group‐housed rats. The pressor response to noradrenaline, which was smaller in isolated rats, was increased to the level of group‐housed controls by (±)‐propranolol. Prolonged isolation of rats may bring about an increase in sensitivity of β‐adrenoceptors to isoprenaline and noradrenaline. 1974 British Pharmacological Society

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SUPERSENSITIVITY TO ISOPRENALINE INDUCED IN RATS BY PROLONGED ISOLATION

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