Suppressible mutations in the cro gene of bacteriophage λ

Ariella Oppenheim, Amos B. Oppenheim*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

The isolation and characterization of suppressible mutations in the cro gene of bacteriophage λ are described. The pleiotropic effect of cro- mutants interferes with phage growth at 30° and at 43°. In this respect, the mutants we isolated were found to be less stringent than the previously studied cro27 mutation. The su2 suppressor present in the C600 host permits plaque formation at 30° but does not suppress the cro-- mutation for growth at 43°. Su6, which inserts leucine into amber mutations, suppresses phage growth at both temperatures. Partial suppression by the su2 suppressor was demonstrated also for the shutoff of exonuclease synthesis. In addition, our results indicate that the cro- mutation and the Nts8 mutation suppress each other for growth at 43°.

Original languageEnglish
Pages (from-to)469-476
Number of pages8
JournalVirology
Volume75
Issue number2
DOIs
StatePublished - Dec 1976

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