TY - JOUR
T1 - Suppression of neuroinflammation and immunomodulation by the acetylcholinesterase inhibitor rivastigmine
AU - Nizri, Eran
AU - Irony-Tur-Sinai, Michal
AU - Faranesh, Nabil
AU - Lavon, Iris
AU - Lavi, Ehud
AU - Weinstock, Marta
AU - Brenner, Talma
PY - 2008/10/15
Y1 - 2008/10/15
N2 - In this study we determined the influence of cholinergic up-regulation by rivastigmine, an acetylcholinesterase inhibitor, on central nervous system inflammation. Neuroinflammation was induced in experimental autoimmune encephalomyelitis (EAE). Rivastigmine markedly ameliorated clinical symptoms of EAE and the spatial memory deficits induced by EAE. It also reduced demyelination, microglia activation and axonal damage. Rivastigmine decreased the reactivity of encephalitogenic T-cells and the production of pro-inflammatory cytokines (TNF-α, IFN-γ and IL-17) without affecting IL-10 production. These effects were abolished by α7 nicotinic acetylcholine receptor antagonists. Antigen presentation was also affected by this treatment. Thus, rivastigmine treatment had immunomodulatory activity in EAE.
AB - In this study we determined the influence of cholinergic up-regulation by rivastigmine, an acetylcholinesterase inhibitor, on central nervous system inflammation. Neuroinflammation was induced in experimental autoimmune encephalomyelitis (EAE). Rivastigmine markedly ameliorated clinical symptoms of EAE and the spatial memory deficits induced by EAE. It also reduced demyelination, microglia activation and axonal damage. Rivastigmine decreased the reactivity of encephalitogenic T-cells and the production of pro-inflammatory cytokines (TNF-α, IFN-γ and IL-17) without affecting IL-10 production. These effects were abolished by α7 nicotinic acetylcholine receptor antagonists. Antigen presentation was also affected by this treatment. Thus, rivastigmine treatment had immunomodulatory activity in EAE.
KW - α7 nicotinic acetylcholine receptor
KW - Acetylcholinesterase inhibitors
KW - Cognitive dysfunction
KW - Experimental autoimmune encephalomyelitis
KW - Multiple sclerosis
UR - http://www.scopus.com/inward/record.url?scp=53149137393&partnerID=8YFLogxK
U2 - 10.1016/j.jneuroim.2008.06.018
DO - 10.1016/j.jneuroim.2008.06.018
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C2 - 18692909
AN - SCOPUS:53149137393
SN - 0165-5728
VL - 203
SP - 12
EP - 22
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
IS - 1
ER -