Suppressors of cancer cell proliferation from fig (Ficus carica) resin: Isolation and structure elucidation

S. Rubnov, Y. Kashman, R. Rabinowitz, M. Schlesinger, R. Mechoulam*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

170 Scopus citations

Abstract

A mixture of 6-O-acyl-β-D-glucosyl-β-sitosterols, the acyl moeity being primarily palmitoyl and linoleyl with minor amounts of stearyl and oleyl, has been isolated as a potent cytotoxic agent from fig (Ficus carica) latex and soybeans. Identity was established by spectroscopic methods (NMR, MS) and confirmed by chemical synthesis. Both the natural and the synthetic compounds showed in vitro inhibitory effects on proliferation of various cancer cell lines.

Original languageEnglish
Pages (from-to)993-996
Number of pages4
JournalJournal of Natural Products
Volume64
Issue number7
DOIs
StatePublished - 2001

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