TY - JOUR
T1 - Supramolecular Chemistry
T2 - Spontaneous structural transition and crystal formation in minimal supramolecular polymer model
AU - Fichman, Galit
AU - Guterman, Tom
AU - Damron, Joshua
AU - Adler-Abramovich, Lihi
AU - Schmidt, Judith
AU - Kesselman, Ellina
AU - Shimon, Linda J.W.
AU - Ramamoorthy, Ayyalusamy
AU - Talmon, Yeshayahu
AU - Gazit, Ehud
N1 - Publisher Copyright:
© 2018 The Authors.
PY - 2016/2
Y1 - 2016/2
N2 - The association of building blocks into supramolecular polymers allows the fabrication of diverse functional architectures at the nanoscale. The use of minimal assembly units to explore polymer dynamics and phase transitions significantly contributes to the application of polymer physicochemical paradigms in the field of supramolecular polymers. We present a minimal model that displays spontaneous coordinated structural transitions between micro-A nd nanostructures, hydrogels with nanoscale order, and single crystals. The simple amphiphilic 9-fluorenylmethoxycarbonyl-3,4-dihydroxyphenylalanine (Fmoc-DOPA) modified amino acid undergoes a noninduced transition from spherical assemblies into nanofibrils followed by sol-gel transition, nanotube formation via intermediate assembly, and crystallization within the gel. Notably, the transition kinetics is slow enough to allow both multistage and multiscale characterization of the supramolecular arrangement using electron microscopy, vibrational and circular dichroism spectroscopies, nuclear magnetic resonance, and X-ray crystallography. This minimalistic system is the first comprehensive model for a complete spontaneous structural transition between diverse states governed by distinct molecular interactions.
AB - The association of building blocks into supramolecular polymers allows the fabrication of diverse functional architectures at the nanoscale. The use of minimal assembly units to explore polymer dynamics and phase transitions significantly contributes to the application of polymer physicochemical paradigms in the field of supramolecular polymers. We present a minimal model that displays spontaneous coordinated structural transitions between micro-A nd nanostructures, hydrogels with nanoscale order, and single crystals. The simple amphiphilic 9-fluorenylmethoxycarbonyl-3,4-dihydroxyphenylalanine (Fmoc-DOPA) modified amino acid undergoes a noninduced transition from spherical assemblies into nanofibrils followed by sol-gel transition, nanotube formation via intermediate assembly, and crystallization within the gel. Notably, the transition kinetics is slow enough to allow both multistage and multiscale characterization of the supramolecular arrangement using electron microscopy, vibrational and circular dichroism spectroscopies, nuclear magnetic resonance, and X-ray crystallography. This minimalistic system is the first comprehensive model for a complete spontaneous structural transition between diverse states governed by distinct molecular interactions.
UR - http://www.scopus.com/inward/record.url?scp=85016864762&partnerID=8YFLogxK
U2 - 10.1126/sciadv.1500827
DO - 10.1126/sciadv.1500827
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AN - SCOPUS:85016864762
SN - 2375-2548
VL - 2
JO - Science advances
JF - Science advances
IS - 2
M1 - e1500827
ER -