TY - GEN
T1 - Surface active phospholipids as cartilage lubricants
AU - Schroedera, Avi
AU - Verberne, Gabi
AU - Merkherc, Yulia
AU - Diminsky, Dvorah
AU - Maroudes, Alice
AU - Halperin, Gregory
AU - Nitzand, Dorrit
AU - Etsionb, Izhak
AU - Barenholz, Yechezkel
AU - Sivan, Sarit
PY - 2009
Y1 - 2009
N2 - Efficient lubrication and extremely low friction are essential for proper functioning of synovial joints. Various joint dysfunctions were described in direct association with increased friction or adhesive forces. Surface-active phospholipids (SAPLs) are well known to reduce friction in synovial joints. This study demonstrates, using a novel human-sourced cartilage-on-cartilage setup, the potential of multilamellar vesicles (MLV) composed of the SAPL dimyristoyl phosphatidylcholine (DMPC) to act as effective lubricants, reducing static and dynamic friction-coefficients to levels of healthy synovial joints. Furthermore, MLV composed of DMPC, in sizes ranging from 0.8 to ̃3.5 urn, were found to be more effective lubricants than histidine buffer, saline, or synovial fluid. The ability to test new cartilage lubricants, simulating, to a great extent, natural conditions, using the setup presented herein is discussed.
AB - Efficient lubrication and extremely low friction are essential for proper functioning of synovial joints. Various joint dysfunctions were described in direct association with increased friction or adhesive forces. Surface-active phospholipids (SAPLs) are well known to reduce friction in synovial joints. This study demonstrates, using a novel human-sourced cartilage-on-cartilage setup, the potential of multilamellar vesicles (MLV) composed of the SAPL dimyristoyl phosphatidylcholine (DMPC) to act as effective lubricants, reducing static and dynamic friction-coefficients to levels of healthy synovial joints. Furthermore, MLV composed of DMPC, in sizes ranging from 0.8 to ̃3.5 urn, were found to be more effective lubricants than histidine buffer, saline, or synovial fluid. The ability to test new cartilage lubricants, simulating, to a great extent, natural conditions, using the setup presented herein is discussed.
UR - https://www.scopus.com/pages/publications/70349161608
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AN - SCOPUS:70349161608
SN - 9780791848364
T3 - 2008 Proceedings of the 9th Biennial Conference on Engineering Systems Design and Analysis
SP - 549
EP - 553
BT - 2008 Proceedings of the 9th Biennial Conference on Engineering Systems Design and Analysis
T2 - 2008 9th Biennial Conference on Engineering Systems Design and Analysis
Y2 - 7 July 2008 through 9 July 2008
ER -