Surface markers and functional characteristics of human blood lymphocytes residing in the operational 'null' subset

T. Bakacs, E. Klein, M. Steinitz, P. Gergeley

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

After removal of nylon wool-adherent B and E rosetting T cells from the human blood lymphocyte population, a small fraction remains, often denoted as 'null' subset. This fraction contains lymphocytes which are highly efficient in antibody-dependent and non-selective lymphocyte cytotoxicity. These cells possess markers. About half of them carry Fc receptors, and the majority has low avidity E and C3 receptors. Removal of low avidity E receptor-carrying cells did not abolish cytotoxicity to K-562 cells. The majority of cells carry receptors for Epstein-Barr virus but cannot be infected. The cells in mixed lymphocyte culture have a low reactivity. They are stimulated by PHA and ConA to a similar extent and differ from the cells which readily sediment as E rosettes: these respond stronger to PHA. The 'null' fraction may contain stem cells common for both T and B lineages.

Original languageEnglish
Pages (from-to)113-126
Number of pages14
JournalHaematologia
Volume12
Issue number1-4
StatePublished - 1978
Externally publishedYes

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