Abstract
After removal of nylon wool-adherent B and E rosetting T cells from the human blood lymphocyte population, a small fraction remains, often denoted as 'null' subset. This fraction contains lymphocytes which are highly efficient in antibody-dependent and non-selective lymphocyte cytotoxicity. These cells possess markers. About half of them carry Fc receptors, and the majority has low avidity E and C3 receptors. Removal of low avidity E receptor-carrying cells did not abolish cytotoxicity to K-562 cells. The majority of cells carry receptors for Epstein-Barr virus but cannot be infected. The cells in mixed lymphocyte culture have a low reactivity. They are stimulated by PHA and ConA to a similar extent and differ from the cells which readily sediment as E rosettes: these respond stronger to PHA. The 'null' fraction may contain stem cells common for both T and B lineages.
Original language | English |
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Pages (from-to) | 113-126 |
Number of pages | 14 |
Journal | Haematologia |
Volume | 12 |
Issue number | 1-4 |
State | Published - 1978 |
Externally published | Yes |