Sustained-Release Delivery Systems for Treatment of Dental Diseases

Michael Friedman*, Doron Steinberg

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

30 Scopus citations


Sustained-release delivery systems allow the effective targeting of drugs for treating dental and periodontal diseases. Since dental diseases are chronic, the therapeutic agents used should persist in the oral cavity for as long as possible. Implanting fluoride, chlorhexidine, and other antiseptic agents embedded into sustained-release polymeric matrices into the oral cavity prevents cariogenic plaque accumulation. Both fibers and slab-like sustained-delivery devices bearing chemotherapeutic agents reduced periopathogenic bacteria levels associated with clinical improvement. This review provides useful background information for researchers seeking to develop controlled-release delivery systems for dental applications.

Original languageAmerican English
Pages (from-to)313-317
Number of pages5
JournalPharmaceutical Research
Issue number4
StatePublished - Apr 1990


  • caries
  • chlorhexidine
  • fluoride
  • local application
  • metronidazole
  • periodontal diseases
  • sustained release
  • tetracycline


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