Abstract
This study reports the development of a system for the sustained release of minocycline for use in the treatment of periodontal diseases. Films of ethylcellulose containing 30% (w/w) minocycline cast from ethanol, chloroform, or chloroform with polyethylene glycol were prepared as sustained release delivery devices. The release rate and the antibacterial activity of minocycline were measured in vitro and in vivo. The results indicate that each formulation studied releases the minocycline at a rate that decreases with time. The release kinetics of minocycline in vivo correlate with the in vitro results. The results of the short-term clinical study indicate that use of the device in periodontal pockets may cause complete eradication of the pathogenic bacteria from the pocket.
Original language | English |
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Pages (from-to) | 231-236 |
Number of pages | 6 |
Journal | Journal of Controlled Release |
Volume | 7 |
Issue number | 3 |
DOIs | |
State | Published - Sep 1988 |