Sustained release device containing minocycline for local treatment of periodontal disease

R. Elkayam, M. Friedman*, A. Stabholz, A. W. Soskolne, M. N. Sela, L. Golub

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

44 Scopus citations

Abstract

This study reports the development of a system for the sustained release of minocycline for use in the treatment of periodontal diseases. Films of ethylcellulose containing 30% (w/w) minocycline cast from ethanol, chloroform, or chloroform with polyethylene glycol were prepared as sustained release delivery devices. The release rate and the antibacterial activity of minocycline were measured in vitro and in vivo. The results indicate that each formulation studied releases the minocycline at a rate that decreases with time. The release kinetics of minocycline in vivo correlate with the in vitro results. The results of the short-term clinical study indicate that use of the device in periodontal pockets may cause complete eradication of the pathogenic bacteria from the pocket.

Original languageEnglish
Pages (from-to)231-236
Number of pages6
JournalJournal of Controlled Release
Volume7
Issue number3
DOIs
StatePublished - Sep 1988

Fingerprint

Dive into the research topics of 'Sustained release device containing minocycline for local treatment of periodontal disease'. Together they form a unique fingerprint.

Cite this