TY - JOUR
T1 - SUVi and BACH1
T2 - A new subfamily of mammalian helicases?
AU - Menichini, Paola
AU - Linial, Michal
PY - 2001/11/1
Y1 - 2001/11/1
N2 - The RecQ family of DNA helicases have been shown to be important for the maintenance of genomic integrity in prokaryotes and eukaryotes. Members of this family are genes responsible for cancer predisposition disorders like Bloom's syndrome, Werner's syndrome and Rothmund-Thomson syndrome. Here, we show the sequence homologies between two recently identified mammalian helicases, namely SUVi and BACH1. These two genes also share strong homologies with other members of the RecQ family. On the basis of published data and sequence analysis we suggest that SUVi/BACH1 may represent a novel subfamily of mammalian helicases, functioning in the processing of lesions induced by different genotoxic agents.
AB - The RecQ family of DNA helicases have been shown to be important for the maintenance of genomic integrity in prokaryotes and eukaryotes. Members of this family are genes responsible for cancer predisposition disorders like Bloom's syndrome, Werner's syndrome and Rothmund-Thomson syndrome. Here, we show the sequence homologies between two recently identified mammalian helicases, namely SUVi and BACH1. These two genes also share strong homologies with other members of the RecQ family. On the basis of published data and sequence analysis we suggest that SUVi/BACH1 may represent a novel subfamily of mammalian helicases, functioning in the processing of lesions induced by different genotoxic agents.
KW - DNA helicases
KW - Genome integrity
KW - Genotoxic stress response
KW - RecQ family
UR - http://www.scopus.com/inward/record.url?scp=0035501412&partnerID=8YFLogxK
U2 - 10.1016/S0921-8777(01)00104-5
DO - 10.1016/S0921-8777(01)00104-5
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C2 - 11595410
AN - SCOPUS:0035501412
SN - 0921-8777
VL - 487
SP - 67
EP - 71
JO - Mutation Research - DNA Repair
JF - Mutation Research - DNA Repair
IS - 1-2
ER -
