SUVi and BACH1: A new subfamily of mammalian helicases?

Paola Menichini, Michal Linial

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


The RecQ family of DNA helicases have been shown to be important for the maintenance of genomic integrity in prokaryotes and eukaryotes. Members of this family are genes responsible for cancer predisposition disorders like Bloom's syndrome, Werner's syndrome and Rothmund-Thomson syndrome. Here, we show the sequence homologies between two recently identified mammalian helicases, namely SUVi and BACH1. These two genes also share strong homologies with other members of the RecQ family. On the basis of published data and sequence analysis we suggest that SUVi/BACH1 may represent a novel subfamily of mammalian helicases, functioning in the processing of lesions induced by different genotoxic agents.

Original languageAmerican English
Pages (from-to)67-71
Number of pages5
JournalMutation Research - DNA Repair
Issue number1-2
StatePublished - 1 Nov 2001


  • DNA helicases
  • Genome integrity
  • Genotoxic stress response
  • RecQ family


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