Sweet Killers: NK Cells Need Glycolysis to Kill Tumors

Batya Isaacson; Ofer Mandelboim

doi:10.1016/j.cmet.2018.07.008

Sweet Killers: NK Cells Need Glycolysis to Kill Tumors

Batya Isaacson, Ofer Mandelboim^*

^*Corresponding author for this work

Department of Immunology and Cancer Research

Research output: Contribution to journal › Short survey › peer-review

16 Scopus citations

Abstract

Natural killer (NK) cells are cytotoxic innate lymphocytes that play a major role in the immune battle against cancer. In this issue of Cell Metabolism, Cong et al. (2018) demonstrate that progressing tumors reduce NK cell glycolytic capacity, which leads to reduced cytotoxicity and an overall dysfunctional NK phenotype. Natural killer (NK) cells are cytotoxic innate lymphocytes that play a major role in the immune battle against cancer. In this issue of Cell Metabolism, Cong et al. (2018) demonstrate that progressing tumors reduce NK cell glycolytic capacity, which leads to reduced cytotoxicity and an overall dysfunctional NK phenotype.

Original language	English
Pages (from-to)	183-184
Number of pages	2
Journal	Cell Metabolism
Volume	28
Issue number	2
DOIs	https://doi.org/10.1016/j.cmet.2018.07.008
State	Published - 7 Aug 2018

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© 2018 Elsevier Inc.

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abstract = "Natural killer (NK) cells are cytotoxic innate lymphocytes that play a major role in the immune battle against cancer. In this issue of Cell Metabolism, Cong et al. (2018) demonstrate that progressing tumors reduce NK cell glycolytic capacity, which leads to reduced cytotoxicity and an overall dysfunctional NK phenotype. Natural killer (NK) cells are cytotoxic innate lymphocytes that play a major role in the immune battle against cancer. In this issue of Cell Metabolism, Cong et al. (2018) demonstrate that progressing tumors reduce NK cell glycolytic capacity, which leads to reduced cytotoxicity and an overall dysfunctional NK phenotype.",

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Sweet Killers: NK Cells Need Glycolysis to Kill Tumors

Abstract

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