Sweet Killers: NK Cells Need Glycolysis to Kill Tumors

Batya Isaacson, Ofer Mandelboim*

*Corresponding author for this work

Research output: Contribution to journalShort surveypeer-review

14 Scopus citations

Abstract

Natural killer (NK) cells are cytotoxic innate lymphocytes that play a major role in the immune battle against cancer. In this issue of Cell Metabolism, Cong et al. (2018) demonstrate that progressing tumors reduce NK cell glycolytic capacity, which leads to reduced cytotoxicity and an overall dysfunctional NK phenotype. Natural killer (NK) cells are cytotoxic innate lymphocytes that play a major role in the immune battle against cancer. In this issue of Cell Metabolism, Cong et al. (2018) demonstrate that progressing tumors reduce NK cell glycolytic capacity, which leads to reduced cytotoxicity and an overall dysfunctional NK phenotype.

Original languageAmerican English
Pages (from-to)183-184
Number of pages2
JournalCell Metabolism
Volume28
Issue number2
DOIs
StatePublished - 7 Aug 2018

Bibliographical note

Publisher Copyright:
© 2018 Elsevier Inc.

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