SWI/SNF chromatin remodeling and cancer

Agnès Klochendler-Yeivin*, Christian Muchardt, Moshe Yaniv

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

148 Scopus citations

Abstract

The SWI/SNF complex contributes to the regulation of gene expression by altering the chromatin structure. Depending on the context, it can be involved in either transcriptional activation or repression. Growing genetic and molecular evidence indicate that subunits of the SWI/SNF complex act as tumor suppressors in human and mice. Results from biochemical and transfection studies suggest also that SWI/SNF participates either in the inhibition or activation of several oncogenes and tumor suppressor genes and/or control their transcriptional activity. These activities provide molecular insight into the mechanism underlying SWI/SNF function in tumor suppression.

Original languageAmerican English
Pages (from-to)73-79
Number of pages7
JournalCurrent Opinion in Genetics and Development
Volume12
Issue number1
DOIs
StatePublished - 1 Feb 2002

Bibliographical note

Funding Information:
We apologize to those whose work was not cited directly because of space constraints. We thank Jonathan Weitzman and Olivier Delattre for critical reading and advice on the manuscript. We thank the AICR Foundation, ARC and LNFCC for financial support.

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