SWI/SNF chromatin remodeling and cancer

Agnès Klochendler-Yeivin; Christian Muchardt; Moshe Yaniv

doi:10.1016/S0959-437X(01)00267-2

SWI/SNF chromatin remodeling and cancer

Agnès Klochendler-Yeivin^*
, Christian Muchardt
, Moshe Yaniv

^*Corresponding author for this work

Department of Developmental Biology and Cancer Research

Research output: Contribution to journal › Review article › peer-review

149 Scopus citations

Abstract

The SWI/SNF complex contributes to the regulation of gene expression by altering the chromatin structure. Depending on the context, it can be involved in either transcriptional activation or repression. Growing genetic and molecular evidence indicate that subunits of the SWI/SNF complex act as tumor suppressors in human and mice. Results from biochemical and transfection studies suggest also that SWI/SNF participates either in the inhibition or activation of several oncogenes and tumor suppressor genes and/or control their transcriptional activity. These activities provide molecular insight into the mechanism underlying SWI/SNF function in tumor suppression.

Original language	English
Pages (from-to)	73-79
Number of pages	7
Journal	Current Opinion in Genetics and Development
Volume	12
Issue number	1
DOIs	https://doi.org/10.1016/S0959-437X(01)00267-2
State	Published - 1 Feb 2002

Bibliographical note

Funding Information:
We apologize to those whose work was not cited directly because of space constraints. We thank Jonathan Weitzman and Olivier Delattre for critical reading and advice on the manuscript. We thank the AICR Foundation, ARC and LNFCC for financial support.

UN SDGs

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SDG 3 Good Health and Well-being

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10.1016/S0959-437X(01)00267-2

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SWI/SNF chromatin remodeling and cancer

Abstract

Bibliographical note

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