Switchable catalytic DNA catenanes

Lianzhe Hu; Chun Hua Lu; Itamar Willner

doi:10.1021/nl504997q

Switchable catalytic DNA catenanes

Lianzhe Hu, Chun Hua Lu, Itamar Willner^*

^*Corresponding author for this work

Institute of Chemistry

Research output: Contribution to journal › Article › peer-review

57 Scopus citations

Abstract

Two-ring interlocked DNA catenanes are synthesized and characterized. The supramolecular catenanes show switchable cyclic catalytic properties. In one system, the catenane structure is switched between a hemin/G-quadruplex catalytic structure and a catalytically inactive state. In the second catenane structure the catenane is switched between a catalytically active Mg²⁺-dependent DNAzyme-containing catenane and an inactive catenane state. In the third system, the interlocked catenane structure is switched between two distinct catalytic structures that include the Mg²⁺- and the Zn²⁺-dependent DNAzymes.

Original language	English
Pages (from-to)	2099-2103
Number of pages	5
Journal	Nano Letters
Volume	15
Issue number	3
DOIs	https://doi.org/10.1021/nl504997q
State	Published - 11 Mar 2015

Bibliographical note

Publisher Copyright:
© 2015 American Chemical Society.

Keywords

chemiluminescence
DNA switch
DNAzyme
hemin/G-quadruplex
machine

Access to Document

10.1021/nl504997q

Cite this

@article{085d92c9a77e4b82b35bd5b3f7694685,

title = "Switchable catalytic DNA catenanes",

abstract = "Two-ring interlocked DNA catenanes are synthesized and characterized. The supramolecular catenanes show switchable cyclic catalytic properties. In one system, the catenane structure is switched between a hemin/G-quadruplex catalytic structure and a catalytically inactive state. In the second catenane structure the catenane is switched between a catalytically active Mg2+-dependent DNAzyme-containing catenane and an inactive catenane state. In the third system, the interlocked catenane structure is switched between two distinct catalytic structures that include the Mg2+- and the Zn2+-dependent DNAzymes.",

keywords = "chemiluminescence, DNA switch, DNAzyme, hemin/G-quadruplex, machine",

author = "Lianzhe Hu and Lu, {Chun Hua} and Itamar Willner",

note = "Publisher Copyright: {\textcopyright} 2015 American Chemical Society.",

year = "2015",

month = mar,

day = "11",

doi = "10.1021/nl504997q",

language = "אנגלית",

volume = "15",

pages = "2099--2103",

journal = "Nano Letters",

issn = "1530-6984",

publisher = "American Chemical Society",

number = "3",

}

TY - JOUR

T1 - Switchable catalytic DNA catenanes

AU - Hu, Lianzhe

AU - Lu, Chun Hua

AU - Willner, Itamar

PY - 2015/3/11

Y1 - 2015/3/11

N2 - Two-ring interlocked DNA catenanes are synthesized and characterized. The supramolecular catenanes show switchable cyclic catalytic properties. In one system, the catenane structure is switched between a hemin/G-quadruplex catalytic structure and a catalytically inactive state. In the second catenane structure the catenane is switched between a catalytically active Mg2+-dependent DNAzyme-containing catenane and an inactive catenane state. In the third system, the interlocked catenane structure is switched between two distinct catalytic structures that include the Mg2+- and the Zn2+-dependent DNAzymes.

AB - Two-ring interlocked DNA catenanes are synthesized and characterized. The supramolecular catenanes show switchable cyclic catalytic properties. In one system, the catenane structure is switched between a hemin/G-quadruplex catalytic structure and a catalytically inactive state. In the second catenane structure the catenane is switched between a catalytically active Mg2+-dependent DNAzyme-containing catenane and an inactive catenane state. In the third system, the interlocked catenane structure is switched between two distinct catalytic structures that include the Mg2+- and the Zn2+-dependent DNAzymes.

KW - chemiluminescence

KW - DNA switch

KW - DNAzyme

KW - hemin/G-quadruplex

KW - machine

UR - http://www.scopus.com/inward/record.url?scp=84924580969&partnerID=8YFLogxK

U2 - 10.1021/nl504997q

DO - 10.1021/nl504997q

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???

C2 - 25642796

AN - SCOPUS:84924580969

SN - 1530-6984

VL - 15

SP - 2099

EP - 2103

JO - Nano Letters

JF - Nano Letters

IS - 3

ER -

Switchable catalytic DNA catenanes

Abstract

Bibliographical note

Keywords

Access to Document

Other files and links

Fingerprint

Cite this