Switchable catalytic DNA catenanes

Lianzhe Hu; Chun Hua Lu; Itamar Willner

doi:10.1021/nl504997q

Switchable catalytic DNA catenanes

Lianzhe Hu
, Chun Hua Lu
, Itamar Willner^*

^*Corresponding author for this work

Institute of Chemistry

Research output: Contribution to journal › Article › peer-review

58 Scopus citations

Abstract

Two-ring interlocked DNA catenanes are synthesized and characterized. The supramolecular catenanes show switchable cyclic catalytic properties. In one system, the catenane structure is switched between a hemin/G-quadruplex catalytic structure and a catalytically inactive state. In the second catenane structure the catenane is switched between a catalytically active Mg²⁺-dependent DNAzyme-containing catenane and an inactive catenane state. In the third system, the interlocked catenane structure is switched between two distinct catalytic structures that include the Mg²⁺- and the Zn²⁺-dependent DNAzymes.

Original language	English
Pages (from-to)	2099-2103
Number of pages	5
Journal	Nano Letters
Volume	15
Issue number	3
DOIs	https://doi.org/10.1021/nl504997q
State	Published - 11 Mar 2015

Bibliographical note

Publisher Copyright:
© 2015 American Chemical Society.

Keywords

DNA switch
DNAzyme
chemiluminescence
hemin/G-quadruplex
machine

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10.1021/nl504997q

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title = "Switchable catalytic DNA catenanes",

abstract = "Two-ring interlocked DNA catenanes are synthesized and characterized. The supramolecular catenanes show switchable cyclic catalytic properties. In one system, the catenane structure is switched between a hemin/G-quadruplex catalytic structure and a catalytically inactive state. In the second catenane structure the catenane is switched between a catalytically active Mg2+-dependent DNAzyme-containing catenane and an inactive catenane state. In the third system, the interlocked catenane structure is switched between two distinct catalytic structures that include the Mg2+- and the Zn2+-dependent DNAzymes.",

keywords = "DNA switch, DNAzyme, chemiluminescence, hemin/G-quadruplex, machine",

author = "Lianzhe Hu and Lu, \{Chun Hua\} and Itamar Willner",

note = "Publisher Copyright: {\textcopyright} 2015 American Chemical Society.",

year = "2015",

month = mar,

day = "11",

doi = "10.1021/nl504997q",

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AU - Hu, Lianzhe

AU - Lu, Chun Hua

AU - Willner, Itamar

PY - 2015/3/11

Y1 - 2015/3/11

N2 - Two-ring interlocked DNA catenanes are synthesized and characterized. The supramolecular catenanes show switchable cyclic catalytic properties. In one system, the catenane structure is switched between a hemin/G-quadruplex catalytic structure and a catalytically inactive state. In the second catenane structure the catenane is switched between a catalytically active Mg2+-dependent DNAzyme-containing catenane and an inactive catenane state. In the third system, the interlocked catenane structure is switched between two distinct catalytic structures that include the Mg2+- and the Zn2+-dependent DNAzymes.

AB - Two-ring interlocked DNA catenanes are synthesized and characterized. The supramolecular catenanes show switchable cyclic catalytic properties. In one system, the catenane structure is switched between a hemin/G-quadruplex catalytic structure and a catalytically inactive state. In the second catenane structure the catenane is switched between a catalytically active Mg2+-dependent DNAzyme-containing catenane and an inactive catenane state. In the third system, the interlocked catenane structure is switched between two distinct catalytic structures that include the Mg2+- and the Zn2+-dependent DNAzymes.

KW - DNA switch

KW - DNAzyme

KW - chemiluminescence

KW - hemin/G-quadruplex

KW - machine

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SN - 1530-6984

VL - 15

SP - 2099

EP - 2103

JO - Nano Letters

JF - Nano Letters

IS - 3

ER -

Switchable catalytic DNA catenanes

Abstract

Bibliographical note

Keywords

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