Switchable Reconfiguration of a Seven-Ring Interlocked DNA Catenane Nanostructure

Chun Hua Lu; Alessandro Cecconello; Xiu Juan Qi; Na Wu; Stefan Sven Jester; Michael Famulok; Michael Matthies; Thorsten Lars Schmidt; Itamar Willner

doi:10.1021/acs.nanolett.5b03280

Switchable Reconfiguration of a Seven-Ring Interlocked DNA Catenane Nanostructure

Chun Hua Lu, Alessandro Cecconello, Xiu Juan Qi, Na Wu, Stefan Sven Jester^*, Michael Famulok, Michael Matthies, Thorsten Lars Schmidt, Itamar Willner

^*Corresponding author for this work

Institute of Chemistry

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Abstract

The synthesis, purification, and structure characterization of a seven-ring interlocked DNA catenane is described. The design of the seven-ring catenane allows the dynamic reconfiguration of any of the four rings (R₁, R₃, R₄, and R₆) on the catenane scaffold, or the simultaneous switching of any combination of two, three, or all four rings to yield 16 different isomeric states of the catenane. The dynamic reconfiguration across the states is achieved by implementing the strand-displacement process in the presence of appropriate fuel/antifuel strands and is probed by fluorescence spectroscopy. Each of the 16 isomers of the catenane can be transformed into any of the other isomers, thus allowing for 240 dynamic transitions within the system.

Original language	English
Pages (from-to)	7133-7137
Number of pages	5
Journal	Nano Letters
Volume	15
Issue number	10
DOIs	https://doi.org/10.1021/acs.nanolett.5b03280
State	Published - 14 Oct 2015

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Publisher Copyright:
© 2015 American Chemical Society.

Keywords

Nanobiotechnology
fluorescence
machine
strand displacement
switch

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10.1021/acs.nanolett.5b03280

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abstract = "The synthesis, purification, and structure characterization of a seven-ring interlocked DNA catenane is described. The design of the seven-ring catenane allows the dynamic reconfiguration of any of the four rings (R1, R3, R4, and R6) on the catenane scaffold, or the simultaneous switching of any combination of two, three, or all four rings to yield 16 different isomeric states of the catenane. The dynamic reconfiguration across the states is achieved by implementing the strand-displacement process in the presence of appropriate fuel/antifuel strands and is probed by fluorescence spectroscopy. Each of the 16 isomers of the catenane can be transformed into any of the other isomers, thus allowing for 240 dynamic transitions within the system.",

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AU - Lu, Chun Hua

AU - Cecconello, Alessandro

AU - Qi, Xiu Juan

AU - Wu, Na

AU - Jester, Stefan Sven

AU - Famulok, Michael

AU - Matthies, Michael

AU - Schmidt, Thorsten Lars

AU - Willner, Itamar

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AB - The synthesis, purification, and structure characterization of a seven-ring interlocked DNA catenane is described. The design of the seven-ring catenane allows the dynamic reconfiguration of any of the four rings (R1, R3, R4, and R6) on the catenane scaffold, or the simultaneous switching of any combination of two, three, or all four rings to yield 16 different isomeric states of the catenane. The dynamic reconfiguration across the states is achieved by implementing the strand-displacement process in the presence of appropriate fuel/antifuel strands and is probed by fluorescence spectroscopy. Each of the 16 isomers of the catenane can be transformed into any of the other isomers, thus allowing for 240 dynamic transitions within the system.

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KW - machine

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Switchable Reconfiguration of a Seven-Ring Interlocked DNA Catenane Nanostructure

Abstract

Bibliographical note

Keywords

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