Switching photonic and electrochemical functions of a DNAzyme by DNA machines

Xiaoqing Liu, Angelica Niazov-Elkan, Fuan Wang, Itamar Willner*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

103 Scopus citations

Abstract

DNA nanostructures acting as DNA machines are described. Specifically, DNA "walkers" assembled on nucleic acid scaffolds and triggered by fuel/antifuel strands are activated in solution or on surfaces, for example, electrodes or semiconductor CdSe/ZnS quantum dots (QDs). The DNA machines led to the switchable formation or dissociation of the hemin/G-quadruplex DNAzyme on the DNA scaffolds. This enabled the chemiluminescence, chemiluminescence resonance energy transfer (CRET), electrochemical, or photoelectrochemical transduction of the switchable states of the different DNA machines.

Original languageEnglish
Pages (from-to)219-225
Number of pages7
JournalNano Letters
Volume13
Issue number1
DOIs
StatePublished - 9 Jan 2013

Keywords

  • chemiluminescence
  • DNA
  • machine
  • nanotechnology
  • quantum dots (QDs)
  • walker

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