Switching photonic and electrochemical functions of a DNAzyme by DNA machines

Xiaoqing Liu; Angelica Niazov-Elkan; Fuan Wang; Itamar Willner

doi:10.1021/nl303894h

Switching photonic and electrochemical functions of a DNAzyme by DNA machines

Xiaoqing Liu, Angelica Niazov-Elkan, Fuan Wang, Itamar Willner^*

^*Corresponding author for this work

Institute of Chemistry

Research output: Contribution to journal › Article › peer-review

103 Scopus citations

Abstract

DNA nanostructures acting as DNA machines are described. Specifically, DNA "walkers" assembled on nucleic acid scaffolds and triggered by fuel/antifuel strands are activated in solution or on surfaces, for example, electrodes or semiconductor CdSe/ZnS quantum dots (QDs). The DNA machines led to the switchable formation or dissociation of the hemin/G-quadruplex DNAzyme on the DNA scaffolds. This enabled the chemiluminescence, chemiluminescence resonance energy transfer (CRET), electrochemical, or photoelectrochemical transduction of the switchable states of the different DNA machines.

Original language	English
Pages (from-to)	219-225
Number of pages	7
Journal	Nano Letters
Volume	13
Issue number	1
DOIs	https://doi.org/10.1021/nl303894h
State	Published - 9 Jan 2013

Keywords

DNA
chemiluminescence
machine
nanotechnology
quantum dots (QDs)
walker

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10.1021/nl303894h

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AU - Willner, Itamar

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Y1 - 2013/1/9

N2 - DNA nanostructures acting as DNA machines are described. Specifically, DNA "walkers" assembled on nucleic acid scaffolds and triggered by fuel/antifuel strands are activated in solution or on surfaces, for example, electrodes or semiconductor CdSe/ZnS quantum dots (QDs). The DNA machines led to the switchable formation or dissociation of the hemin/G-quadruplex DNAzyme on the DNA scaffolds. This enabled the chemiluminescence, chemiluminescence resonance energy transfer (CRET), electrochemical, or photoelectrochemical transduction of the switchable states of the different DNA machines.

AB - DNA nanostructures acting as DNA machines are described. Specifically, DNA "walkers" assembled on nucleic acid scaffolds and triggered by fuel/antifuel strands are activated in solution or on surfaces, for example, electrodes or semiconductor CdSe/ZnS quantum dots (QDs). The DNA machines led to the switchable formation or dissociation of the hemin/G-quadruplex DNAzyme on the DNA scaffolds. This enabled the chemiluminescence, chemiluminescence resonance energy transfer (CRET), electrochemical, or photoelectrochemical transduction of the switchable states of the different DNA machines.

KW - DNA

KW - chemiluminescence

KW - machine

KW - nanotechnology

KW - quantum dots (QDs)

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Switching photonic and electrochemical functions of a DNAzyme by DNA machines

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Keywords

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