Synaptic plasticity mediating cocaine relapse requires matrix metalloproteinases

Alexander C.W. Smith; Yonatan M. Kupchik; Michael D. Scofield; Cassandra D. Gipson; Armina Wiggins; Charles A. Thomas; Peter W. Kalivas

doi:10.1038/nn.3846

Synaptic plasticity mediating cocaine relapse requires matrix metalloproteinases

Alexander C.W. Smith, Yonatan M. Kupchik, Michael D. Scofield, Cassandra D. Gipson, Armina Wiggins, Charles A. Thomas, Peter W. Kalivas^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

100 Scopus citations

Abstract

Relapse to cocaine use necessitates remodeling excitatory synapses in the nucleus accumbens and synaptic reorganization requires matrix metalloproteinase (MMP) degradation of the extracellular matrix proteins. We found enduring increases in MMP-2 activity in rats after withdrawal from self-administered cocaine and transient increases in MMP-9 during cue-induced cocaine relapse. Cue-induced heroin and nicotine relapse increased MMP activity, and increased MMP activity was required for both cocaine relapse and relapse-associated synaptic plasticity.

Original language	American English
Pages (from-to)	1655-1657
Number of pages	3
Journal	Nature Neuroscience
Volume	17
Issue number	12
DOIs	https://doi.org/10.1038/nn.3846
State	Published - 1 Jan 2014
Externally published	Yes

Bibliographical note

Funding Information:
This research was support by US National Institutes of Health grants DA003906, DA012513 and DA015369.

Publisher Copyright:
© 2014 Nature America, Inc. All rights reserved.

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abstract = "Relapse to cocaine use necessitates remodeling excitatory synapses in the nucleus accumbens and synaptic reorganization requires matrix metalloproteinase (MMP) degradation of the extracellular matrix proteins. We found enduring increases in MMP-2 activity in rats after withdrawal from self-administered cocaine and transient increases in MMP-9 during cue-induced cocaine relapse. Cue-induced heroin and nicotine relapse increased MMP activity, and increased MMP activity was required for both cocaine relapse and relapse-associated synaptic plasticity.",

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Synaptic plasticity mediating cocaine relapse requires matrix metalloproteinases

Abstract

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