Synaptic plasticity mediating cocaine relapse requires matrix metalloproteinases

Alexander C.W. Smith; Yonatan M. Kupchik; Michael D. Scofield; Cassandra D. Gipson; Armina Wiggins; Charles A. Thomas; Peter W. Kalivas

doi:10.1038/nn.3846

Synaptic plasticity mediating cocaine relapse requires matrix metalloproteinases

Alexander C.W. Smith, Yonatan M. Kupchik, Michael D. Scofield, Cassandra D. Gipson, Armina Wiggins, Charles A. Thomas, Peter W. Kalivas^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

111 Scopus citations

Abstract

Relapse to cocaine use necessitates remodeling excitatory synapses in the nucleus accumbens and synaptic reorganization requires matrix metalloproteinase (MMP) degradation of the extracellular matrix proteins. We found enduring increases in MMP-2 activity in rats after withdrawal from self-administered cocaine and transient increases in MMP-9 during cue-induced cocaine relapse. Cue-induced heroin and nicotine relapse increased MMP activity, and increased MMP activity was required for both cocaine relapse and relapse-associated synaptic plasticity.

Original language	English
Pages (from-to)	1655-1657
Number of pages	3
Journal	Nature Neuroscience
Volume	17
Issue number	12
DOIs	https://doi.org/10.1038/nn.3846
State	Published - 1 Jan 2014
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2014 Nature America, Inc. All rights reserved.

Access to Document

10.1038/nn.3846

Cite this

@article{3ca61818bfc24ba6b65f5244abf57b75,

title = "Synaptic plasticity mediating cocaine relapse requires matrix metalloproteinases",

abstract = "Relapse to cocaine use necessitates remodeling excitatory synapses in the nucleus accumbens and synaptic reorganization requires matrix metalloproteinase (MMP) degradation of the extracellular matrix proteins. We found enduring increases in MMP-2 activity in rats after withdrawal from self-administered cocaine and transient increases in MMP-9 during cue-induced cocaine relapse. Cue-induced heroin and nicotine relapse increased MMP activity, and increased MMP activity was required for both cocaine relapse and relapse-associated synaptic plasticity.",

author = "Smith, {Alexander C.W.} and Kupchik, {Yonatan M.} and Scofield, {Michael D.} and Gipson, {Cassandra D.} and Armina Wiggins and Thomas, {Charles A.} and Kalivas, {Peter W.}",

year = "2014",

month = jan,

day = "1",

doi = "10.1038/nn.3846",

language = "אנגלית",

volume = "17",

pages = "1655--1657",

journal = "Nature Neuroscience",

issn = "1097-6256",

publisher = "Nature Publishing Group",

number = "12",

}

TY - JOUR

T1 - Synaptic plasticity mediating cocaine relapse requires matrix metalloproteinases

AU - Smith, Alexander C.W.

AU - Kupchik, Yonatan M.

AU - Scofield, Michael D.

AU - Gipson, Cassandra D.

AU - Wiggins, Armina

AU - Thomas, Charles A.

AU - Kalivas, Peter W.

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Relapse to cocaine use necessitates remodeling excitatory synapses in the nucleus accumbens and synaptic reorganization requires matrix metalloproteinase (MMP) degradation of the extracellular matrix proteins. We found enduring increases in MMP-2 activity in rats after withdrawal from self-administered cocaine and transient increases in MMP-9 during cue-induced cocaine relapse. Cue-induced heroin and nicotine relapse increased MMP activity, and increased MMP activity was required for both cocaine relapse and relapse-associated synaptic plasticity.

AB - Relapse to cocaine use necessitates remodeling excitatory synapses in the nucleus accumbens and synaptic reorganization requires matrix metalloproteinase (MMP) degradation of the extracellular matrix proteins. We found enduring increases in MMP-2 activity in rats after withdrawal from self-administered cocaine and transient increases in MMP-9 during cue-induced cocaine relapse. Cue-induced heroin and nicotine relapse increased MMP activity, and increased MMP activity was required for both cocaine relapse and relapse-associated synaptic plasticity.

UR - http://www.scopus.com/inward/record.url?scp=84925226691&partnerID=8YFLogxK

U2 - 10.1038/nn.3846

DO - 10.1038/nn.3846

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???

C2 - 25326689

AN - SCOPUS:84925226691

SN - 1097-6256

VL - 17

SP - 1655

EP - 1657

JO - Nature Neuroscience

JF - Nature Neuroscience

IS - 12

ER -

Synaptic plasticity mediating cocaine relapse requires matrix metalloproteinases

Abstract

Bibliographical note

Access to Document

Other files and links

Fingerprint

Cite this