Synaptic plasticity: Multiple forms, functions, and mechanisms

Ami Citri; Robert C. Malenka

doi:10.1038/sj.npp.1301559

Synaptic plasticity: Multiple forms, functions, and mechanisms

Ami Citri, Robert C. Malenka^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

1447 Scopus citations

Abstract

Experiences, whether they be learning in a classroom, a stressful event, or ingestion of a psychoactive substance, impact the brain by modifying the activity and organization of specific neural circuitry. A major mechanism by which the neural activity generated by an experience modifies brain function is via modifications of synaptic transmission; that is, synaptic plasticity. Here, we review current understanding of the mechanisms of the major forms of synaptic plasticity at excitatory synapses in the mammalian brain. We also provide examples of the possible developmental and behavioral functions of synaptic plasticity and how maladaptive synaptic plasticity may contribute to neuropsychiatric disorders.

Original language	English
Pages (from-to)	18-41
Number of pages	24
Journal	Neuropsychopharmacology
Volume	33
Issue number	1
DOIs	https://doi.org/10.1038/sj.npp.1301559
State	Published - Jan 2008
Externally published	Yes

Bibliographical note

Funding Information:
RM gratefully acknowledges support from NIMH, NIDA, NINDS, and NARSAD. AC acknowledges the support of the The International Human Frontier Science Program Organization. We apologize to those colleagues whose work was not cited because of the large scope of this review and severe space limitations.

Keywords

AMPA receptors
Addiction
Hippocampus
Long-term depression
Long-term potentiation
NMDA receptors

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10.1038/sj.npp.1301559

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Synaptic plasticity: Multiple forms, functions, and mechanisms

Abstract

Bibliographical note

Keywords

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