Synaptic Recruitment Enhances Gap Termination Responses in Auditory Cortex

Bshara Awwad, Maciej M. Jankowski, Israel Nelken*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

The ability to detect short gaps in noise is an important tool for assessing the temporal resolution in the auditory cortex. However, the mere existence of responses to temporal gaps bounded by two short broadband markers is surprising, because of the expected short-term suppression that is prevalent in auditory cortex. Here, we used in-vivo intracellular recordings in anesthetized rats to dissect the synaptic mechanisms that underlie gap-related responses. When a gap is bounded by two short markers, a gap termination response was evoked by the onset of the second marker with minimal contribution from the offset of the first marker. Importantly, we show that the gap termination response was driven by a different (potentially partially overlapping) synaptic population than that underlying the onset response to the first marker. This recruitment of additional synaptic resources is a novel mechanism contributing to the important perceptual task of gap detection.

Original languageAmerican English
Pages (from-to)4465-4480
Number of pages16
JournalCerebral Cortex
Volume30
Issue number8
DOIs
StatePublished - 30 Jun 2020

Bibliographical note

Publisher Copyright:
© 2020 The Author(s) 2020. Published by Oxford University Press.

Keywords

  • auditory cortex
  • gap detection
  • rat
  • short-term plasticity
  • stimulus-specific adaptation

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