Synaptogenesis in the adult CNS-olfactory system

A. Mizrahi, A. Vinograd

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

1 Scopus citations


The olfactory system of mammals, and the olfactory bulb (OB) in particular, provides a rich repository of new synapses. In the OB, new synapses are being formed continuously and are eliminated in high numbers relative to other regions of the mammalian central nervous system. The relatively high rate of synaptic turnover comes from several neuronal sources. Both the axonal inputs and the local interneurons are being formed continuously to replace older cells and synapses. These sources add to the normal maintenance and plastic demands of any neuronal circuit. In this chapter, some of the current knowledge regarding synaptogenesis in the olfactory system is reviewed. The topics treated include the basic architecture of the underlying neural circuits, the main synaptic types that turn over, some of the mechanisms that may be responsible for replacing large numbers of synapses, and their functional implication.

Original languageAmerican English
Title of host publicationSynapse Development and Maturation
Subtitle of host publicationComprehensive Developmental Neuroscience
Number of pages20
ISBN (Electronic)9780128236727
StatePublished - 1 Jan 2020

Bibliographical note

Publisher Copyright:
© 2020 Elsevier Inc.


  • Adult neurogenesis
  • Dendrodendritic synapses
  • Deprivation
  • Electrophysiology
  • Granule cell
  • Mitral cells
  • Olfactory bulb
  • Olfactory receptor neuron
  • Periglomerular neuron
  • Plasticity
  • Sensory enrichment
  • Smell
  • Time-lapse imaging
  • Two-photon imaging


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