TY - JOUR
T1 - Synchrony of rest tremor in multiple limbs in Parkinson's disease
T2 - Evidence for multiple oscillators
AU - Ben-Pazi, H.
AU - Bergman, H.
AU - Goldberg, J. A.
AU - Giladi, N.
AU - Hansel, D.
AU - Reches, A.
AU - Simon, E. S.
PY - 2001
Y1 - 2001
N2 - Recent evidence points to involvement of central nervous system oscillators in Parkinson's disease (PD) rest tremor. It remains unknown whether one or multiple oscillators cause tremor in multiple limbs. Based on the prediction that multiple oscillators would cause low coherence even with similar average frequency, we studied 22 PD patients using accelerometers on multiple limbs. Records were digitized and spectral analysis was performed. Peak frequencies in the arms, legs, and chin were similar, indicating that biomechanical factors did not determine the frequency. Coherence between different axes of individual accelerometers and between different segments of the same limb was high. However, coherence between tremor in different limbs was low. There was no consistent pattern across patients of ipsi- vs. contralateral predominance of coherence. These data suggest that tremor in PD is generated by multiple oscillatory circuits, which operate on similar frequencies.
AB - Recent evidence points to involvement of central nervous system oscillators in Parkinson's disease (PD) rest tremor. It remains unknown whether one or multiple oscillators cause tremor in multiple limbs. Based on the prediction that multiple oscillators would cause low coherence even with similar average frequency, we studied 22 PD patients using accelerometers on multiple limbs. Records were digitized and spectral analysis was performed. Peak frequencies in the arms, legs, and chin were similar, indicating that biomechanical factors did not determine the frequency. Coherence between different axes of individual accelerometers and between different segments of the same limb was high. However, coherence between tremor in different limbs was low. There was no consistent pattern across patients of ipsi- vs. contralateral predominance of coherence. These data suggest that tremor in PD is generated by multiple oscillatory circuits, which operate on similar frequencies.
KW - Basal ganglia
KW - Coherence
KW - Oscillations
KW - Parkinson's disease
KW - Synchrony
KW - Tremor
UR - http://www.scopus.com/inward/record.url?scp=0034906042&partnerID=8YFLogxK
U2 - 10.1007/s007020170074
DO - 10.1007/s007020170074
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C2 - 11341480
AN - SCOPUS:0034906042
SN - 0300-9564
VL - 108
SP - 287
EP - 296
JO - Journal of Neural Transmission
JF - Journal of Neural Transmission
IS - 3
ER -