Syntheses of Amide Derivatives of DL-β-Carboxy-γ-aminobutyric Acid

Albert Zilkha, Uri Golik

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Amides of DL-β-carboxy-γ-aminobutyric acid have been synthesized, starting with itaconic anhydride. This was opened by the appropriate amine to yield 2-methylene-N-alkylsuccinamic acids, to the double bond of which one mole of benzylamine was added. Hydrogenolysis of the resulting benzylamine derivatives gave the required amides of the free amino acid. The structure of the 2-methylene-N-alkylsuccinamic acids is established.

Original languageEnglish
Pages (from-to)2007-2009
Number of pages3
JournalJournal of Organic Chemistry
Volume28
Issue number8
DOIs
StatePublished - 1 Aug 1963

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