Synthesis and biological activity of NK-1 selective, N-backbone cyclic analogs of the C-terminal hexapeptide of substance P

Keyphrases

• Biological Activity 100%
• Substance P 100%
• Hexapeptide 100%
• NK-1 100%
• Cyclic Analogs 100%
• Cyclization 66%
• Amino-terminus 33%
• Resin 33%
• Molecular Modeling 33%
• Side Chain 33%
• NMR Data 33%
• Main Chain 33%
• Solid Phase 33%
• Ring Width 33%
• Protecting Groups 33%
• Backbone Cyclization 33%
• Data-driven Modeling 33%
• Metabolic Stability 33%
• Mass Spectroscopy 33%
• Tissue Preparation 33%
• P-analogue 33%
• Fmoc Chemistry 33%
• Boc Chemistry 33%
• Neurokinin-1 Receptor (NK1R) 33%

Chemistry

• Bioactivity 100%
• Substance P 100%
• Chemistry 66%
• NMR Spectroscopy 33%
• Mass Spectrometry 33%
• Metabolic 33%
• High Performance Liquid Chromatography 33%
• Protecting Groups 33%
• NMR Data 33%
• Arg-Phe 33%
• Phe-Phe 33%
• stability 33%
• Molecular Model 33%
• Leu-Met 33%

Biochemistry, Genetics and Molecular Biology

• C-Terminus 100%
• Biological Activity 100%
• Substance P 100%
• N-Terminus 33%
• High-Performance Liquid Chromatography 33%
• Molecular Model 33%
• Solid 33%
• Tachykinin Receptor 33%
• Arginine 33%
• Tissue Preparation 33%