Synthesis and biological evaluation of lipophilic iron chelators as protective agents from oxidative stress

The biological evaluation and synthesis of lipophilic iron chelators as protective agents from oxidative stress were analyzed. A spontaneously transformed cell line of oligodendroglia origin (OLN 93) was chose as a model for neural cells. These cells were used to demonstrate remarkable sensitivity to geontoxic stress, culminating in cell death when both divalent iron and H ₂O₂ were added to cells. OLN 93 cells were seeded in 96-well polyethyleneimine precoated plates, and after 24 h attachment were further incubated for 3 h with the synthetic analog at various concentrations. The results show the proactive effect of analog 5-7 at a 200 μM.