Synthesis and biological evaluation of lipophilic iron chelators as protective agents from oxidative stress

Eylon Yavin, Raghavendra Kikkiri, Shosh Gil, Rina Arad-Yellin, Ephraim Yavin, Abraham Shanzer*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

11 Scopus citations

Abstract

The biological evaluation and synthesis of lipophilic iron chelators as protective agents from oxidative stress were analyzed. A spontaneously transformed cell line of oligodendroglia origin (OLN 93) was chose as a model for neural cells. These cells were used to demonstrate remarkable sensitivity to geontoxic stress, culminating in cell death when both divalent iron and H 2O2 were added to cells. OLN 93 cells were seeded in 96-well polyethyleneimine precoated plates, and after 24 h attachment were further incubated for 3 h with the synthetic analog at various concentrations. The results show the proactive effect of analog 5-7 at a 200 μM.

Original languageAmerican English
Pages (from-to)2685-2687
Number of pages3
JournalOrganic and Biomolecular Chemistry
Volume3
Issue number15
DOIs
StatePublished - 7 Aug 2005
Externally publishedYes

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