Polychloromethylstyrene nanoparticles of sizes from 12.0±2.3 to 229.6±65 nm were prepared by the emulsion and miniemulsion polymerization of chloromethylstyrene in an aqueous continuous phase in the presence of potassium persulfate as initiator, sodium octylbenzenesulfonate as surfactant, and hexadecane as costabilizer for the miniemulsion polymerization process only. The influence of various polymerization parameters (e.g., concentration of the monomer, initiator, the crosslinker monomer, and the surfactant) on the properties of the particles (e.g., size, size distribution, and yield) has been elucidated. The polychloromethylstyrene nanoparticles formed via the emulsion polymerization mechanism possess smaller diameter and size distribution than those formed under similar conditions via the miniemulsion polymerization mechanism. Other differences between these two polymerization mechanisms have also been elucidated. For future study, we wish to use these nanoparticles for the covalent immobilization of bioactive reagents such as proteins to the surface of these nanoparticles for various biomedical applications.
Bibliographical noteFunding Information:
These studies were partially supported by a Minerva Grant (Microscale & Nanoscale Particles and Films). The authors would like to thank Dr. Yossi Gofer from Bar-Ilan University, Department of Chemistry for his help in the XPS study.
- Emulsion polymerization
- Miniemulsion polymerization
- Polychloromethylstyrene nanoparticles