Cationic amphiphiles derived from trehalose have been synthesized; trehalose analogues substituted with n-pentyl or n-hexyl ethers exhibited membrane disrupting activities against clinically important Gram positive and Gram negative bacteria and fungi. Our results demonstrate that trehalose is a useful disaccharide scaffold for the development of broad-spectrum antimicrobial and antifungal agents.
Bibliographical noteFunding Information:
This study was supported by the Israel Science Foundation Grant 6/14. We thank Prof. Judith Berman from the Department of Molecular Microbiology and Biotechnology, The George S. Wise Faculty of Life Sciences, Tel Aviv University for her generous gift of the Candida strains.
© The Royal Society of Chemistry 2016.