Synthesis and evaluation of membrane permeabilizing properties of cationic amphiphiles derived from the disaccharide trehalose

P. Shaul, R. I. Benhamou, I. M. Herzog, S. Louzoun Zada, Y. Ebenstein, M. Fridman*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Cationic amphiphiles derived from trehalose have been synthesized; trehalose analogues substituted with n-pentyl or n-hexyl ethers exhibited membrane disrupting activities against clinically important Gram positive and Gram negative bacteria and fungi. Our results demonstrate that trehalose is a useful disaccharide scaffold for the development of broad-spectrum antimicrobial and antifungal agents.

Original languageAmerican English
Pages (from-to)3012-3015
Number of pages4
JournalOrganic and Biomolecular Chemistry
Volume14
Issue number11
DOIs
StatePublished - 2016
Externally publishedYes

Bibliographical note

Publisher Copyright:
© The Royal Society of Chemistry 2016.

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