Synthesis and evaluation of membrane permeabilizing properties of cationic amphiphiles derived from the disaccharide trehalose

P. Shaul; R. I. Benhamou; I. M. Herzog; S. Louzoun Zada; Y. Ebenstein; M. Fridman

doi:10.1039/c6ob00031b

Synthesis and evaluation of membrane permeabilizing properties of cationic amphiphiles derived from the disaccharide trehalose

P. Shaul
, R. I. Benhamou
, I. M. Herzog
, S. Louzoun Zada
, Y. Ebenstein
, M. Fridman^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Cationic amphiphiles derived from trehalose have been synthesized; trehalose analogues substituted with n-pentyl or n-hexyl ethers exhibited membrane disrupting activities against clinically important Gram positive and Gram negative bacteria and fungi. Our results demonstrate that trehalose is a useful disaccharide scaffold for the development of broad-spectrum antimicrobial and antifungal agents.

Original language	English
Pages (from-to)	3012-3015
Number of pages	4
Journal	Organic and Biomolecular Chemistry
Volume	14
Issue number	11
DOIs	https://doi.org/10.1039/c6ob00031b
State	Published - 2016
Externally published	Yes

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© The Royal Society of Chemistry 2016.

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AU - Ebenstein, Y.

AU - Fridman, M.

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Synthesis and evaluation of membrane permeabilizing properties of cationic amphiphiles derived from the disaccharide trehalose

Abstract

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