TY - JOUR
T1 - Synthesis and Functionalization of Thiophosphonium Salts
T2 - A Divergent Approach to Access Thioether, Thioester, and Dithioester Derivatives
AU - Hazra, Gurupada
AU - Masarwa, Ahmad
N1 - Publisher Copyright:
© 2023 The Authors. Published by American Chemical Society.
PY - 2023/9/1
Y1 - 2023/9/1
N2 - Herein, we report a straightforward practical method for efficiently obtaining a diverse range of thiophosphonium salts. This method involves the direct coupling of commercially available thiols and aldehydes with Ph3P and TfOH. The setup is simple and carried out in a metal-free manner. The synthetic utility of these salts is demonstrated through various examples of C-P bond functionalizations, enabling the synthesis of thioether, deuterated thioether, thioester, and dithioester derivatives. These products, which serve as valuable building blocks, are obtained in high yields.
AB - Herein, we report a straightforward practical method for efficiently obtaining a diverse range of thiophosphonium salts. This method involves the direct coupling of commercially available thiols and aldehydes with Ph3P and TfOH. The setup is simple and carried out in a metal-free manner. The synthetic utility of these salts is demonstrated through various examples of C-P bond functionalizations, enabling the synthesis of thioether, deuterated thioether, thioester, and dithioester derivatives. These products, which serve as valuable building blocks, are obtained in high yields.
UR - http://www.scopus.com/inward/record.url?scp=85169503680&partnerID=8YFLogxK
U2 - 10.1021/acs.orglett.3c02422
DO - 10.1021/acs.orglett.3c02422
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C2 - 37610079
AN - SCOPUS:85169503680
SN - 1523-7060
VL - 25
SP - 6396
EP - 6400
JO - Organic Letters
JF - Organic Letters
IS - 34
ER -