TY - JOUR
T1 - Synthesis and Polymerization of p‐Vinyl‐β‐Phenylethylamine
AU - Tahan, M.
AU - Lender, N.
AU - Zilkha, A.
PY - 1972
Y1 - 1972
N2 - p‐Vinyl benzyl chloride was converted to p‐vinyl benzyl cyanide which was reduced to p‐vinyl‐β‐phenyl‐ethylamine with lithium aluminium hydride. The amine gave an insoluble polymer on heating with azo initiator, but soluble polymer was obtained on polymerizing p‐vinyl‐β‐phenylethylamine hydrochloride in aqueous solution by bisulfite/persulfate initiator. Preliminary pharmacological tests carried out on poly‐p‐vinyl‐β‐phenylethylamine hydrochloride and its monomer, showed that the polymer was much more toxic, it showed a tranquilizer/sedative action compared to the monomer which showed excitor symptoms.
AB - p‐Vinyl benzyl chloride was converted to p‐vinyl benzyl cyanide which was reduced to p‐vinyl‐β‐phenyl‐ethylamine with lithium aluminium hydride. The amine gave an insoluble polymer on heating with azo initiator, but soluble polymer was obtained on polymerizing p‐vinyl‐β‐phenylethylamine hydrochloride in aqueous solution by bisulfite/persulfate initiator. Preliminary pharmacological tests carried out on poly‐p‐vinyl‐β‐phenylethylamine hydrochloride and its monomer, showed that the polymer was much more toxic, it showed a tranquilizer/sedative action compared to the monomer which showed excitor symptoms.
UR - http://www.scopus.com/inward/record.url?scp=84987313876&partnerID=8YFLogxK
U2 - 10.1002/ijch.197200084
DO - 10.1002/ijch.197200084
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AN - SCOPUS:84987313876
SN - 0021-2148
VL - 10
SP - 835
EP - 839
JO - Israel Journal of Chemistry
JF - Israel Journal of Chemistry
IS - 4
ER -