Synthesis of a bicyclic BPTI mimetic containing 4-thioproline replacing Cys38

Ron Kasher; Gal Bitan; Christeen Halloun; Chaim Gilon

doi:10.1007/BF02443447

Synthesis of a bicyclic BPTI mimetic containing 4-thioproline replacing Cys³⁸

Ron Kasher, Gal Bitan, Christeen Halloun, Chaim Gilon^*

^*Corresponding author for this work

Institute of Chemistry

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

The synthesis of a backbone bicyclic nonapeptide that mimics the binding site of bovine pancreatic trypsin inhibitor (BPTI) is described. The BPTI mimetic, which contains cis-thioproline replacing Cys³⁸ of the protein, inhibits trypsin with a K_i of 76 μM.

Original language	English
Pages (from-to)	101-103
Number of pages	3
Journal	Letters in Peptide Science
Volume	5
Issue number	2-3
DOIs	https://doi.org/10.1007/BF02443447
State	Published - 1998

Keywords

4-thioproline
BPTI
Backbone cyclic peptides
Bovine pancreatic trypsin inhibitor
Peptidomimetic
Proteinomimetic

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10.1007/BF02443447

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title = "Synthesis of a bicyclic BPTI mimetic containing 4-thioproline replacing Cys38",

abstract = "The synthesis of a backbone bicyclic nonapeptide that mimics the binding site of bovine pancreatic trypsin inhibitor (BPTI) is described. The BPTI mimetic, which contains cis-thioproline replacing Cys38 of the protein, inhibits trypsin with a Ki of 76 μM.",

keywords = "4-thioproline, BPTI, Backbone cyclic peptides, Bovine pancreatic trypsin inhibitor, Peptidomimetic, Proteinomimetic",

author = "Ron Kasher and Gal Bitan and Christeen Halloun and Chaim Gilon",

year = "1998",

doi = "10.1007/BF02443447",

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AU - Kasher, Ron

AU - Bitan, Gal

AU - Halloun, Christeen

AU - Gilon, Chaim

PY - 1998

Y1 - 1998

N2 - The synthesis of a backbone bicyclic nonapeptide that mimics the binding site of bovine pancreatic trypsin inhibitor (BPTI) is described. The BPTI mimetic, which contains cis-thioproline replacing Cys38 of the protein, inhibits trypsin with a Ki of 76 μM.

AB - The synthesis of a backbone bicyclic nonapeptide that mimics the binding site of bovine pancreatic trypsin inhibitor (BPTI) is described. The BPTI mimetic, which contains cis-thioproline replacing Cys38 of the protein, inhibits trypsin with a Ki of 76 μM.

KW - 4-thioproline

KW - BPTI

KW - Backbone cyclic peptides

KW - Bovine pancreatic trypsin inhibitor

KW - Peptidomimetic

KW - Proteinomimetic

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Synthesis of a bicyclic BPTI mimetic containing 4-thioproline replacing Cys³⁸

Abstract

Keywords

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