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Synthesis of a novel macrocyclic library: Discovery of an IGF-1R inhibitor
Nir Qvit
, Hadas Reuveni
, Sharon Gazal
, Adi Zundelevich
,
Galia Blum
,
Masha Y. Niv
, Alexandra Feldstein
, Sharon Meushar
,
Deborah E. Shalev
,
Assaf Friedler
,
Chaim Gilon
*
*
Corresponding author for this work
School of Pharmacy
Institute of Biochemistry, Food Science and Nutrition
Department of Biological Chemistry
Institute of Chemistry
Research output
:
Contribution to journal
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Article
›
peer-review
26
Scopus citations
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Keyphrases
A1 Receptor
25%
Activation Loop
25%
Aldehydes
25%
Amino Acids
25%
Amino-functionalized
25%
Biological Activity
50%
Biologically Active
25%
Chemical Synthesis
25%
Disulfide
25%
Growth Factors
25%
High Diversity
25%
IGF1R Inhibitor
100%
Insulin-like
25%
Library Discovery
100%
Macromolecular Scaffolds
25%
Macromolecules
25%
Pharmacophore
100%
Small Molecules
25%
Spatial Arrangement
25%
Tea-bag Method
25%
Chemistry
Aldehyde
50%
Amino Acid
50%
Bioactivity
100%
Disulfide
50%
Insulin-Like Growth Factor 1
50%
Macromolecule
50%
Biochemistry, Genetics and Molecular Biology
Amino Acids
25%
Biological Activity
50%
Conformation
25%
Disulfide
25%
Insulin-Like Growth Factor 1 Receptor
25%
Macromolecule
25%
Pharmacophore
100%
Small Molecule
25%