Synthesis of a silicon-containing analogue of chloramphenicol

Max Frankel*, Mordechai Broze, David Gertner, Albert Zilkha

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

A silicon-containing analogue of chloramphenicol, 2-dichloroacetamido-1-(p- trimethylsilylphenyl)propan-1,3-diol, has been prepared from p-trimethylsilylbenzaldehyde by condensation with glycine, reduction of p-trimethylsilylphenylserine to 2-amino-1-(p-trimethylsilylphenyl)propan-1,3- diol, and dichloroacetylation. The chloramphenicol analogue has the threo configuration.

Original languageEnglish
Pages (from-to)249-250
Number of pages2
JournalJournal of the Chemical Society C: Organic Chemistry
DOIs
StatePublished - 1966

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