TY - JOUR
T1 - Synthesis of a silicon-containing analogue of chloramphenicol
AU - Frankel, Max
AU - Broze, Mordechai
AU - Gertner, David
AU - Zilkha, Albert
PY - 1966
Y1 - 1966
N2 - A silicon-containing analogue of chloramphenicol, 2-dichloroacetamido-1-(p- trimethylsilylphenyl)propan-1,3-diol, has been prepared from p-trimethylsilylbenzaldehyde by condensation with glycine, reduction of p-trimethylsilylphenylserine to 2-amino-1-(p-trimethylsilylphenyl)propan-1,3- diol, and dichloroacetylation. The chloramphenicol analogue has the threo configuration.
AB - A silicon-containing analogue of chloramphenicol, 2-dichloroacetamido-1-(p- trimethylsilylphenyl)propan-1,3-diol, has been prepared from p-trimethylsilylbenzaldehyde by condensation with glycine, reduction of p-trimethylsilylphenylserine to 2-amino-1-(p-trimethylsilylphenyl)propan-1,3- diol, and dichloroacetylation. The chloramphenicol analogue has the threo configuration.
UR - http://www.scopus.com/inward/record.url?scp=37049115682&partnerID=8YFLogxK
U2 - 10.1039/j39660000249
DO - 10.1039/j39660000249
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C2 - 5948240
AN - SCOPUS:37049115682
SN - 0022-4952
SP - 249
EP - 250
JO - Journal of the Chemical Society C: Organic Chemistry
JF - Journal of the Chemical Society C: Organic Chemistry
ER -