TY - JOUR
T1 - Synthesis of antibodies against measles virus and myelin by in vitro stimulated B-cells derived from patients with subacute sclerosing panencephalitis
AU - Wirguin, Itzhak
AU - Steinitz, Michael
AU - Sicsic, Camille
AU - Abramsky, Oded
AU - Brenner, Talma
PY - 1993/9
Y1 - 1993/9
N2 - Subacute sclerosing panencephalitis (SSPE) patients carry persistent measles virus infection in the brain. Furthermore, the blood lymphocytes contain viral RNA. Lymphocytes derived from 6 SSPE patients were stimulated with Epstein-Barr virus (EBV). Production of antibodies against measles virus of the IgG isotype was detected in the supernatants of cell cultures of all patients, regardless of the disease's activity, duration or interferon therapy. In contrast, only some of these cell cultures also produced antibodies against myelin.
AB - Subacute sclerosing panencephalitis (SSPE) patients carry persistent measles virus infection in the brain. Furthermore, the blood lymphocytes contain viral RNA. Lymphocytes derived from 6 SSPE patients were stimulated with Epstein-Barr virus (EBV). Production of antibodies against measles virus of the IgG isotype was detected in the supernatants of cell cultures of all patients, regardless of the disease's activity, duration or interferon therapy. In contrast, only some of these cell cultures also produced antibodies against myelin.
KW - Anti-measles virus antibody
KW - Epstein-Barr virus-stimulated B-cell
KW - Galactocerebroside
KW - Myelin basic protein
KW - Subacute sclerosing panencephalitis
UR - http://www.scopus.com/inward/record.url?scp=0027428108&partnerID=8YFLogxK
U2 - 10.1016/0165-2478(93)90118-L
DO - 10.1016/0165-2478(93)90118-L
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C2 - 7507883
AN - SCOPUS:0027428108
SN - 0165-2478
VL - 38
SP - 55
EP - 58
JO - Immunology Letters
JF - Immunology Letters
IS - 1
ER -
