Synthesis of aromatic aldehydes by oxidative hydroxymethylation

Oiena Branytska, Ronny Neumann*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

A new high yield method for the synthesis of aromatic aldehydes has been developed. The procedure is based on an acid catalyzed hydroxymethylation of an arene substrate by paraformaldehyde with concurrent selective oxidation of the intermediate aromatic carbinol by 2,3-dichloro-5,6-dicyanobenzoquinone (DDQ) to the aldehyde product.

Original languageEnglish
Pages (from-to)1575-1576
Number of pages2
JournalSynlett
Issue number9
DOIs
StatePublished - 22 Jul 2004
Externally publishedYes

Keywords

  • Aldehydes
  • Arenes
  • Electrophilic aromatic substitutions
  • Oxidations
  • Quinones

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