Abstract
A new high yield method for the synthesis of aromatic aldehydes has been developed. The procedure is based on an acid catalyzed hydroxymethylation of an arene substrate by paraformaldehyde with concurrent selective oxidation of the intermediate aromatic carbinol by 2,3-dichloro-5,6-dicyanobenzoquinone (DDQ) to the aldehyde product.
Original language | English |
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Pages (from-to) | 1575-1576 |
Number of pages | 2 |
Journal | Synlett |
Issue number | 9 |
DOIs | |
State | Published - 22 Jul 2004 |
Externally published | Yes |
Keywords
- Aldehydes
- Arenes
- Electrophilic aromatic substitutions
- Oxidations
- Quinones