Synthesis of asymmetrical diaminobis(alkoxo)-bisphenol compounds and their C 1-symmetrical mono-ligated titanium(iv) complexes as highly stable highly active antitumor compounds

Gilad Nahari, Edit Y. Tshuva*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Asymmetrical 2,2′-((ethane-1,2-diylbis((2-hydroxyethyl)azanediyl))bis(methylene))diphenol substituted compounds and their C1-symmetrical diaminobis(phenolato)-bis(alkoxo) titanium(iv) complexes were synthesized, with one symmetrical analogue. X-ray crystallography corroborated tight ligand binding. Different substitutions on the two aromatic rings enabled fine-tuning of the complex properties, giving enhanced solubility, high anticancer activity (IC50 < 4 μM), and significant hydrolytic stability.

Original languageAmerican English
Pages (from-to)6423-6426
Number of pages4
JournalDalton Transactions
Volume50
Issue number19
DOIs
StatePublished - 21 May 2021

Bibliographical note

Publisher Copyright:
© 2021 The Royal Society of Chemistry.

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