Synthesis of asymmetrical diaminobis(alkoxo)-bisphenol compounds and their C 1-symmetrical mono-ligated titanium(iv) complexes as highly stable highly active antitumor compounds

Gilad Nahari; Edit Y. Tshuva

doi:10.1039/d1dt00219h

Synthesis of asymmetrical diaminobis(alkoxo)-bisphenol compounds and their C ₁-symmetrical mono-ligated titanium(iv) complexes as highly stable highly active antitumor compounds

Gilad Nahari, Edit Y. Tshuva^*

^*Corresponding author for this work

Institute of Chemistry

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Asymmetrical 2,2′-((ethane-1,2-diylbis((2-hydroxyethyl)azanediyl))bis(methylene))diphenol substituted compounds and their C1-symmetrical diaminobis(phenolato)-bis(alkoxo) titanium(iv) complexes were synthesized, with one symmetrical analogue. X-ray crystallography corroborated tight ligand binding. Different substitutions on the two aromatic rings enabled fine-tuning of the complex properties, giving enhanced solubility, high anticancer activity (IC50 < 4 μM), and significant hydrolytic stability.

Original language	English
Pages (from-to)	6423-6426
Number of pages	4
Journal	Dalton Transactions
Volume	50
Issue number	19
DOIs	https://doi.org/10.1039/d1dt00219h
State	Published - 21 May 2021

Bibliographical note

Publisher Copyright:
© 2021 The Royal Society of Chemistry.

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10.1039/d1dt00219h

Cite this

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abstract = "Asymmetrical 2,2′-((ethane-1,2-diylbis((2-hydroxyethyl)azanediyl))bis(methylene))diphenol substituted compounds and their C1-symmetrical diaminobis(phenolato)-bis(alkoxo) titanium(iv) complexes were synthesized, with one symmetrical analogue. X-ray crystallography corroborated tight ligand binding. Different substitutions on the two aromatic rings enabled fine-tuning of the complex properties, giving enhanced solubility, high anticancer activity (IC50 < 4 μM), and significant hydrolytic stability.",

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