Synthesis of cell-impermeable inhibitor of phospholipase A2

Saul Yedgar; Nurit Reisfeld; Arie Dagan

doi:10.1016/0014-5793(86)80531-2

Synthesis of cell-impermeable inhibitor of phospholipase A₂

Saul Yedgar^*, Nurit Reisfeld, Arie Dagan

^*Corresponding author for this work

Racah Institute of Physics

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Phospholipase A₂ (PLA₂) in the cell surface membrane is considered a regulator of cellular secretion. The distinction between the role of the cell surface and the intracellular PLA₂ is not clear, since it has not been possible to differentiate unequivocally the activity of the enzymes in the various organelles. The use of an extracellular inhibitor of PLA₂ can greatly contribute to the understanding of cell surface PLA₂ function. In this paper, the preparation of a cell-impermeable inhibitor of PLA₂ is presented. This substance incorporates into lipid membranes and is capable of blocking the hydrolysis of membrane phospholipids by snake venom as well as by cell membrane PLA₂.

Original language	English
Pages (from-to)	165-168
Number of pages	4
Journal	FEBS Letters
Volume	200
Issue number	1
DOIs	https://doi.org/10.1016/0014-5793(86)80531-2
State	Published - 5 May 1986

Keywords

Phospholipase A Cell-impermeable inhibitor

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10.1016/0014-5793(86)80531-2

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AB - Phospholipase A2 (PLA2) in the cell surface membrane is considered a regulator of cellular secretion. The distinction between the role of the cell surface and the intracellular PLA2 is not clear, since it has not been possible to differentiate unequivocally the activity of the enzymes in the various organelles. The use of an extracellular inhibitor of PLA2 can greatly contribute to the understanding of cell surface PLA2 function. In this paper, the preparation of a cell-impermeable inhibitor of PLA2 is presented. This substance incorporates into lipid membranes and is capable of blocking the hydrolysis of membrane phospholipids by snake venom as well as by cell membrane PLA2.

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Synthesis of cell-impermeable inhibitor of phospholipase A₂

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Keywords

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